Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects
Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects
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DOI：
10.1002/bdrc.20117
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发表时间：
2008-03-01
影响因子：
2.1
通讯作者：
Murray, Jeffrey C.
中科院分区：
文献类型：
--
作者：
Shi, Min;Wehby, George L.;Murray, Jeffrey C.
一系列不良妊娠结局，包括早产、低出生体重和出生缺陷，都与母亲在怀孕期间吸烟有关。本文包括一个审查的研究，调查遗传变异和母亲吸烟之间的相互作用，有助于出生缺陷，使用口裂作为模型出生缺陷。其他主要出生缺陷的主要基因吸烟研究也进行了总结。出生缺陷的基因-环境相互作用研究仍处于早期阶段，结果喜忧参半，但不断发展的研究结果已开始记录临床和发育重要的相互作用。随着样本和数据越来越多，需要更多的努力来设计创新的分析方法来研究基因-环境相互作用。
A spectrum of adverse pregnancy outcomes, including preterm birth, low birth weight, and birth defects has been linked with maternal smoking during pregnancy. This article includes a review of studies investigating interactions between genetic variants and maternal smoking in contributing to birth defects using oral clefting as a model birth defect. The primary gene-smoking studies for other major birth defects are also summarized. Gene-environment interaction studies for birth defects are still at an early stage with several mixed results, but evolving research findings have begun to document clinically and developmentally important interactions. As samples and data become increasingly available, more effort is needed in designing innovative analytical methods to study gene-environment interactions.