Conformational dynamics of actin: effectors and implications for biological function.

Conformational dynamics of actin: effectors and implications for biological function.
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DOI:
10.1002/cm.20473
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发表时间:
2010-10
期刊:
影响因子:
2.9
通讯作者:
Nyitrai, Miklos
Nyitrai, Miklos
中科院分区:
生物学4区
文献类型:
--
作者:
Hild, Gabor;Bugyi, Beata;Nyitrai, Miklos

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Actin is a protein abundant in many cell types. Decades of investigations have provided evidence that it has many functions in living cells. The diverse morphology and dynamics of actin structures adapted to versatile cellular functions is established by a large repertoire of actin-binding proteins. The proper interactions with these proteins assume effective molecular adaptations from actin, in which its conformational transitions play essential role. This review attempts to summarise our current knowledge regarding the coupling between the conformational states of actin and its biological function.
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