The long and winding road to the mitochondrial pyruvate carrier.
The long and winding road to the mitochondrial pyruvate carrier.
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DOI：
10.1186/2049-3002-1-6
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发表时间：
2013-01-23
影响因子：
5.9
通讯作者：
Rutter J
中科院分区：
文献类型：
--
作者：
Schell JC;Rutter J
从燃料代谢中提取能量和生物合成构件是生命的基本必需品。通过细胞酶的作用，复杂的碳结构在与产生高能磷酸盐(如ATP和GTP)以及电子载体(如NADH和FADH2)的反应中被分解。这些过程穿过细胞内的隔间，以获得特定的酶和环境。丙酮酸是胞质糖酵解的最终产物，有多种可能的命运，其中最主要的是线粒体氧化。虽然这种代谢物已经知道跨越线粒体内膜几十年了，但直到最近才发现这种活性所需的蛋白质。这篇综述将记录40多年来 对这一关键过程的研究，并将讨论这一发现对癌症新陈代谢的一些可能的影响。
The extraction of energy and biosynthetic building blocks from fuel metabolism is a fundamental requisite for life. Through the action of cellular enzymes, complex carbon structures are broken down in reactions coupled to the production of high-energy phosphates as in ATP and GTP as well as electron carriers such as NADH and FADH2. These processes traverse across compartments inside the cell in order to access specific enzymes and environments. Pyruvate is the end product of cytosolic glycolysis and has a variety of possible fates, the major one being mitochondrial oxidation. While this metabolite has been known to cross the inner mitochondrial membrane for decades, it is only recently that proteins necessary for this activity have been identified. This review will chronicle more than 40 years of research interrogating this critical process and will discuss some of the possible implications of this discovery for cancer metabolism.