G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia
G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia
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G-CSF 和神经保护：脑缺血的治疗视角。
DOI：
10.1042/bst0341327
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发表时间：
2006-12-01
影响因子：
3.9
通讯作者：
Xiao, B. -G.
中科院分区：
文献类型：
--
作者：
Lu, C. -Z.;Xiao, B. -G.
在脑缺血的实验研究中，粒细胞集落刺激因子（granulocytecolon-stimulatingfactor，G-CSF）通过动员造血干细胞、抗凋亡、神经元分化、血管生成和抗炎等机制发挥神经保护作用。因此，G-CSF不仅抑制神经元死亡，而且还产生“新的”神经组织形成。一项小型先导试验报告了G-CSF治疗中风患者的安全性和可行性。根据这一证据，我们可以推测，G-CSF，无论是单独使用或与另一种药物联合使用，应具有双重活性，既有利于急性神经元保护和脑缺血后的长期可塑性，从而提出G-CSF是一个理想的新的药物治疗中风和神经退行性疾病。
In several experimental studies of cerebral ischaemia, G-CSF (granulocyte colony-stimulating factor) exerted neuroprotective effects through different mechanisms, including mobilization of haemopoietic stem cells, anti-apoptosis, neuronal differentiation, angiogenesis and anti-inflammation. Hence, G-CSF not only inhibits neuron death, but also generates 'new' neural tissue formation. A small pilot trial reports on the safety and feasibility of G-CSF therapy in stroke patients. According to this evidence, we can speculate that G-CSF, being used either alone or in combination with another agent, should have a dual activity beneficial both to acute neuronal protection and long-term plasticity after cerebral ischaemia, thus proposing that G-CSF is an ideal new drug for stroke and neurodegenerative diseases.