Role of aberrant protein modification, assembly, and localization in cloned embryo phenotypes.
Role of aberrant protein modification, assembly, and localization in cloned embryo phenotypes.
复制标题
DOI：
10.1007/978-1-4939-0817-2_7
复制
发表时间：
2014
影响因子：
--
通讯作者：
K. Latham
中科院分区：
文献类型：
--
作者：
K. Latham
蛋白质翻译后异常修饰是克隆胚胎异常特征的重要原因。这篇综述总结了蛋白质修饰和蛋白质相互作用的异常方面，对细胞采取了从内到外的观点。这些异常方面影响着一系列过程，包括染色质结构的控制、多能基因的表达、表观遗传的传播、蛋白质的运输、定位和信号传递、细胞骨架结构、有丝分裂和膜蛋白的正确定位。通过观察克隆胚胎的这些异常特征，它们是如何产生的，以及它们对发育的影响，有可能深入了解正常发育并确定提高克隆结果的新策略。
Aberrant post-translational modifications of proteins contribute markedly to the abnormal characteristics of cloned embryos. This review summarizes aberrant aspects of protein modifications and protein interactions, taking an inside–outside view to the cell. These aberrant aspects affect a range of processes including the control of chromatin structure, expression of pluripotency genes, propagation of epigenetic inheritance, protein trafficking, localization and signaling, cytoskeletal structure, mitosis, and correct localization of membrane proteins. By observing these aberrant features of cloned embryos, how they arise, and their impacts on development, it is possible to gain insight into normal development and identify novel strategies for enhancing cloning outcomes.