A EAACI drug allergy interest group survey on how European allergy specialists deal with β-lactam allergy
A EAACI drug allergy interest group survey on how European allergy specialists deal with β-lactam allergy
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DOI：
10.1111/all.13721
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发表时间：
2019-06-01
期刊：
影响因子：
12.4
通讯作者：
Romano, Antonino
中科院分区：
文献类型：
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作者：
Jose Torres, Maria;Celik, Gulfem Elif;Romano, Antonino
准确诊断β-内酰胺（BL）过敏可降低患者发病率和死亡率。我们的目的是研究BL试剂的可用性，它们在欧洲不同地区的使用和检测程序，以及用于评价BL超敏反应受试者的诊断检查的任何差异。在2016年2月至4月期间，通过电子邮件向EAACI药物过敏兴趣小组（DAIG）的所有成员发送了一份调查问卷，该问卷旨在研究疑似BL超敏反应的管理。调查问卷通过电子邮件发送到82个DAIG中心，并得到57个中心的答复。阿莫西林单用或与克拉维酸联合使用是最常见的BL，但丹麦中心除外，在丹麦中心，青霉素V是最常见的疑似BL。所有中心均对有BL过敏史的受试者进行过敏检查：53个中心（93%）遵循DAIG指南、2个国家指南和2个地方指南。然而，有偏离DAIG建议有关过敏试验，特别是药物激发试验。目前的做法不仅在各国之间，而且在同一个国家内的各中心之间，都存在着很大的差异。这表明有必要重新评估，更新和标准化的协议管理疑似BL过敏的患者。
An accurate diagnosis of beta-lactam (BL) allergy can reduce patient morbidity and mortality. Our aim was to investigate the availability of BL reagents, their use and test procedures in different parts of Europe, as well as any differences in the diagnostic workups for evaluating subjects with BL hypersensitivity. A survey was emailed to all members of the EAACI Drug Allergy Interest Group (DAIG) between February and April 2016, and the questionnaire was meant to study the management of suspected BL hypersensitivity. The questionnaire was emailed to 82 DAIG centres and answered by 57. Amoxicillin alone or combined to clavulanic acid were the most commonly involved BL except in the Danish centre, where penicillin V was the most frequently suspected BL. All centres performed an allergy workup in subjects with histories of hypersensitivity to BL: 53 centres (93%) followed DAIG guidelines, two national guidelines and two local guidelines. However, there were deviations from DAIG recommendations concerning allergy tests, especially drug provocation tests. A significant heterogeneity exists in current practice not only among countries, but also among centres within the same country. This suggests the need to re-evaluate, update and standardize protocols on the management of patients with suspected BL allergy.