Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits
Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits
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DOI：
10.1016/j.bmcl.2009.01.019
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发表时间：
2009-03-01
影响因子：
2.7
通讯作者：
Lee, Seokjoon
中科院分区：
文献类型：
--
作者：
Ahn, Chan Mug;Park, Byong-Gon;Lee, Seokjoon
为了发现新的小血管舒张分子用于治疗血管疾病的潜在用途，我们测试了两种类型的合成姜黄素模拟物（酰胺型（3）和磺酰胺型（4））对兔基底动脉的血管舒张作用。通常，磺酰胺型模拟物（4）比酰胺型（3）更有效。姜黄素（1）和化合物12和20有效地扩张了白色家兔的基底动脉。皇冠版权所有（C）2009由爱思唯尔有限公司出版。保留所有权利。
In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.