Stealing the Show: KSHV Hijacks Host RNA Regulatory Pathways to Promote Infection.
Stealing the Show: KSHV Hijacks Host RNA Regulatory Pathways to Promote Infection.
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DOI：
10.3390/v12091024
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发表时间：
2020-09-14
期刊：
影响因子：
--
通讯作者：
Muller M
中科院分区：
文献类型：
--
作者：
Macveigh-Fierro D;Rodriguez W;Miles J;Muller M
卡波西氏肉瘤相关疱疹病毒（KSHV）诱导终身感染，并已进化出多种方式对其宿主的转录和转录后机制施加广泛控制，以更好地获取资源并抑制免疫感知。这种接管的标志是KSHV如何重塑RNA的命运，既控制自身基因的表达，也控制宿主基因的表达。从细胞核到细胞质，RNA表达、定位和衰变的控制是一个由多种因素精心调节的过程，可以适应或对环境的快速变化作出反应。有趣的是，KSHV似乎已经找到了利用这些途径的方法来造福自己。在这里，我们提供了一个全面的审查，最近的工作在这一领域，特别是在转录后修饰前沿的最新进展。总的来说，这篇综述强调了KSHV用于控制RNA命运的无数方法，并收集了过去十年在RNA生物学和KSHV研究领域的研究中获得的新见解。
Kaposi’s sarcoma-associated herpesvirus (KSHV) induces life-long infections and has evolved many ways to exert extensive control over its host’s transcriptional and post-transcriptional machinery to gain better access to resources and dampened immune sensing. The hallmark of this takeover is how KSHV reshapes RNA fate both to control expression of its own gene but also that of its host. From the nucleus to the cytoplasm, control of RNA expression, localization, and decay is a process that is carefully tuned by a multitude of factors and that can adapt or react to rapid changes in the environment. Intriguingly, it appears that KSHV has found ways to co-opt each of these pathways for its own benefit. Here we provide a comprehensive review of recent work in this area and in particular recent advances on the post-transcriptional modifications front. Overall, this review highlights the myriad of ways KSHV uses to control RNA fate and gathers novel insights gained from the past decade of research at the interface of RNA biology and the field of KSHV research.
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