Association between cardiovascular risk profiles and the presence and extent of different types of coronary atherosclerotic plaque as detected by multidetector computed tomography
Association between cardiovascular risk profiles and the presence and extent of different types of coronary atherosclerotic plaque as detected by multidetector computed tomography
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DOI：
10.1161/atvbaha.107.155010
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发表时间：
2008-03-01
影响因子：
8.7
通讯作者：
Hoffmann, Udo
中科院分区：
文献类型：
--
作者：
Bamberg, Fabian;Dannemann, Nina;Hoffmann, Udo
目的：评估心血管危险因素与非钙化(NCAP)、混合型(MCAP)和钙化冠状动脉粥样硬化斑块(CAP)的程度之间的关系。方法和结果：在这项横断面研究中，我们纳入了连续的受试者，他们表现为胸痛，但没有冠状动脉疾病(CAD)病史，也没有发生急性冠状动脉综合征。采用多层螺旋CT冠状动脉多层螺旋CT增强扫描，以确定冠状动脉各节段是否存在NCAP、MCAP和CAP。在195名患者(91名女性，平均年龄：54.6+/-12.0)中，11名患者(5.6%)仅检出NCAP。NCAP范围随年龄增长而减少，MCAP和CAP范围随年龄增长而增加(P=0.06，P=0.02，P=0.13)。在调整其他危险因素后，高脂血症和冠心病家族史与NCAP的程度相关(分别为P=0.02和P=0.04)，与MCAP和CAP的程度相关(分别为P=0.02和P=0.05)。结论：仅有一小部分个体具有NCAP，提示NCAP和CAP的关系随年龄的变化而变化。在个体危险因素中，高脂血症和冠心病家族史可能与NCAP的严重程度有关。为了证实我们的发现，需要进行更大规模的观察性试验。
Objective-To assess the association between cardiovascular risk factors and extent of noncalcified-(NCAP), mixed( MCAP), and calcified coronary atherosclerotic plaque (CAP).Methods and Results-In this cross-sectional study, we included consecutive subjects who presented with chest pain but had no history of coronary artery disease (CAD) and did not develop acute coronary syndrome. Contrast-enhanced 64-slice coronary MDCT was performed to determine the presence of NCAP, MCAP, and CAP for each coronary segment. Among 195 patients (91 women, mean age: 54.6 +/- 12.0) exclusively NCAP was detected in 11 patients (5.6%). The extent of NCAP decreased and the extent of MCAP and CAP increased with age (P=0.06, P=0.02, and P=0.13, respectively). Hyperlipidemia and family history of CAD were associated with the extent of NCAP after adjusting for other risk factors (P=0.02 and P=0.04, respectively) or for the extent of MCAP and CAP (P=0.02 and P=0.05, respectively).Conclusions-Our data suggest that only a small proportion of individuals have exclusively NCAP and indicate that the relation of NCAP and CAP changes with age. Among individual risk factors, hyperlipidemia and family history of CAD may be associated with the extent of NCAP. Larger observational trials are necessary to confirm our findings.