Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis
Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis
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DOI：
10.1016/j.bmcl.2006.08.099
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发表时间：
2006-12-01
影响因子：
2.7
通讯作者：
Ueoka, Ryuichi
中科院分区：
文献类型：
--
作者：
Komizu, Yuji;Matsumoto, Yoko;Ueoka, Ryuichi
由90mol%二肉豆蔻酰磷脂酰胆碱和10mol%十二烷基聚氧乙烯醚组成的混合脂质体（HL）对人结肠癌（WiDr）细胞生长的50%抑制浓度与HL细胞膜流动性具有良好的相关性。HL区分WiDr和正常结肠细胞，然后融合并积聚到WiDr细胞的膜中，导致凋亡。(c)2006爱思唯尔有限公司版权所有。
A good correlation between 50% inhibitory concentration of hybrid liposomes (HL) composed of 90 mol% dimyristoylphosphatidylcholine and 10 mol% polyoxyethylene(n)dodecyl ether on the growth of human colon tumor (WiDr) cells, and membrane fluidity of HL was obtained. HL distinguished between WiDr and normal colon cells and then fused and accumulated into the membranes of WiDr cells leading to apoptosis. (c) 2006 Elsevier Ltd. All rights reserved.