Tgf-beta signaling pathway in lung adenocarcinoma invasion.
Tgf-beta signaling pathway in lung adenocarcinoma invasion.
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DOI：
10.1097/jto.0b013e3181c8cc0c
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Powell CA
中科院分区：
文献类型：
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作者：
Toonkel RL;Borczuk AC;Powell CA
细支气管肺泡癌（BAC）与其他腺癌的组织学区别在于组织浸润。肺腺癌侵袭的临床重要性得到了最近几项研究的支持，这些研究表明，非粘液性BAC的死亡风险显著低于纯侵袭性肿瘤和纤维化或线性侵袭大于0.6 cm的肿瘤。利用人类肿瘤的微阵列基因表达谱，转化生长因子-β（TGF-β）信号转导的失调被鉴定为肿瘤侵袭的重要介质。随后的研究表明，CC趋化因子RANTES（调节激活，正常T细胞表达，并推测分泌）在侵袭性肿瘤中上调，并且是TGF-β II型受体水平受抑制的细胞中侵袭所需的。总之，这些研究说明了如何从肿瘤的全球表达谱中获得的信息可以用于识别介导肿瘤生长，侵袭和转移的关键途径和基因。
The histological distinction between bronchioloalveolar carcinoma (BAC) and other adenocarcinomas is tissue invasion. The clinical importance of lung adenocarcinoma invasion is supported by several recent studies indicating that the risk of death in non-mucinous BAC is significantly lower than that of pure invasive tumors and in tumors with greater than 0.6 cm of fibrosis or linear invasion. Using microarray gene expression profiling of human tumors, dysregulation of transforming growth factor-ß (TGF-ß) signaling was identified as an important mediator of tumor invasion. Subsequent studies showed that the CC chemokine RANTES (Regulated on Activation, Normal T-cell Expressed, and presumably Secreted) was upregulated in invasive tumors and was required for invasion in cells with repressed levels of the TGF-ß type II receptor. Taken together, these studies illustrate how information gained from global expression profiling of tumors can be used to identify key pathways and genes mediating tumor growth, invasion, and metastasis.