GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-7-5p in pancreatic cancer
GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-7-5p in pancreatic cancer
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GFR α 2 通过 Mir-7-5p 下调胰腺癌肿瘤抑制基因 PTEN，促进细胞生长和化疗耐药
DOI：
10.1016/j.canlet.2016.06.016
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发表时间：
2016-10-01
期刊：
影响因子：
9.7
通讯作者：
Peng, Chenghong
中科院分区：
文献类型：
--
作者：
Gu, Jiangning;Wang, Di;Peng, Chenghong
神经生长因子及其受体在肿瘤的发生、生物学过程和转移中起重要作用，在肿瘤的发生、发展中起着重要的作用。在这里，我们的目的是描述一种新的功能，一种亚型的生长因子受体（GFR），GFR α（2），在胰腺癌。在这项研究中，我们发现GFR α（2）在胰腺癌中上调，并与肿瘤大小和神经周围浸润呈正相关，这表明它可能与细胞生长和凋亡有关。在机制上，我们发现高GFR α（2）表达水平通过提高Mir-17- 5 p水平导致PTEN失活。(C)2016作者（S）出版社：Elsevier爱尔兰Ltd.
Nerve growth factors and their receptors have received an increasing attention in certain cancers since they play an important role in regulating tumorigenesis, biological process and metastasis. Here we aimed at characterizing a new function of one of the subtypes of growth factor receptors (GFR), GFR alpha(2), in pancreatic cancer. In this study, we showed that GFR alpha(2) was up-regulated in pancreatic adenocarcinoma and was positively correlated with tumor size and perineural invasion, which indicated that it may be associated with cell growth and apoptosis. Mechanically, we discovered that high GFR alpha(2) expression level leads to PTEN inactivation via enhancing Mir-17-5p level. (C) 2016 The Author(s). Published by Elsevier Ireland Ltd.