Extraction of trace tilmicosin in real water samples using ionic liquid-based aqueous two-phase systems.
Extraction of trace tilmicosin in real water samples using ionic liquid-based aqueous two-phase systems.
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DOI：
10.2166/wst.2013.015
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发表时间：
2013-04
期刊：
影响因子：
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通讯作者：
Ru Pan;Dejia Shao;Xue-yong Qi;Yuning Wu;Wenyan Fu;Yan-ru Ge;Haizhen Fu
中科院分区：
文献类型：
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作者：
Ru Pan;Dejia Shao;Xue-yong Qi;Yuning Wu;Wenyan Fu;Yan-ru Ge;Haizhen Fu
采用离子液体(IL)(1-丁基-3-甲基咪唑氯，[C4mim]Cl)和无机盐(K2HPO4)双水相萃取-高效液相色谱联用的方法，从0.45μm滤膜的实际水样中萃取痕量替米考星。考察了不同盐类、K2HPO4浓度、ILS浓度、体系pH值和温度对萃取率的影响。在最佳条件下，平均萃取率可达95.8%。该方法用于实际水样中替米考星的分析是可行的，测定范围为0.5~40μg m L(-1)。该方法的检出限为0.05μg mL(-1)。该方法对实际水样中替米考星的回收率为92.0-99.0%。该工艺对替米考星的提取具有重要的应用价值。
The effective method of ionic liquid-based aqueous two-phase extraction, which involves ionic liquid (IL) (1-butyl-3-methyllimidazolium chloride, [C4mim]Cl) and inorganic salt (K2HPO4) coupled with high-performance liquid chromatography (HPLC), has been used to extract trace tilmicosin in real water samples which were passed through a 0.45 μm filter. The effects of the different types of salts, the concentration of K2HPO4 and of ILs, the pH value and temperature of the systems on the extraction efficiencies have all been investigated. Under the optimum conditions, the average extraction efficiency is up to 95.8%. This method was feasible when applied to the analysis of tilmicosin in real water samples within the range 0.5-40 μg mL(-1). The limit of detection was found to be 0.05 μg mL(-1). The recovery rate of tilmicosin was 92.0-99.0% from the real water samples by the proposed method. This process is suggested to have important applications for the extraction of tilmicosin.