The significance of premature luteinization in an oocyte-donation programme
The significance of premature luteinization in an oocyte-donation programme
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DOI：
10.1093/humrep/dei474
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发表时间：
2006-06-01
影响因子：
6.1
通讯作者：
Remohi, J.
中科院分区：
文献类型：
--
作者：
Melo, M. A. B.;Meseguer, M.;Remohi, J.
背景：许多证据表明，过早黄体化（PL）可能影响IVF结局。本研究的主要终点是验证PL对我们的卵母细胞捐赠计划的妊娠率（PR）的影响。方法：以HCG日血清孕酮≥ 1.2ng/ml为PL。我们回顾性分析了240个卵母细胞捐赠周期，其中120名妇女捐赠了两次，在第一个捐赠周期中有PL，在下一个捐赠周期中没有PL，作为自己的对照。受体（n = 240）根据PL的存在（n = 120）或不存在（n = 120）分为两组。比较两组供体周期参数和受体周期结局。结果：两组之间的PR没有差异（分别为55.7%和54.4%）。在孕酮< 1.2 ng/ml和PL的供体中，总卵母细胞数（18.2 +/-0.6 vs 20.8 +/- 0.6; P = 0.003）和获得的成熟卵母细胞数（16.9 +/- 0.6 vs 19.4 +/- 0.6; P = 0.005）分别不同。在受精、卵裂、第3天胚胎分裂、囊胚发育或碎裂率方面，两种卵母细胞受体之间没有差异。移植的胚胎数量、冷冻保存的胚胎数量以及植入和流产率在两组之间相似。结论：在我们的卵母细胞捐赠计划中，PL似乎对持续的PR没有负面影响。
BACKGROUND: Several evidences indicate that premature luteinization (PL) may affect IVF outcome. The primary end-point of the present study was to verify the effect of PL on the pregnancy rate (PR) of our oocytedonation programme. METHODS: PL was defined as serum progesterone >= 1.2 ng/ml on the day of HCG. We analysed retrospectively 240 oocyte-donation cycles in which 120 women donated twice, with PL in the first donation cycle and no PL in the following one, acting as its own control. Recipients (n = 240) were divided in two groups according to the presence of PL (n = 120) or not (n = 120). Both groups were compared regarding donor cycle parameters and recipient cycle outcome. RESULTS: There was no difference in PR between the groups (55.7 versus 54.4%, respectively). The number of total oocytes (18.2 +/- 0.6 versus 20.8 +/- 0.6; P = 0.003) and the number of mature oocytes retrieved (16.9 +/- 0.6 versus 19.4 +/- 0.6; P = 0.005) were different among donors with progesterone < 1.2 ng/ml and PL, respectively. There were no differences between the oocyte recipients in fertilization, cleavage, embryo division on day 3, blastocyst development or fragmentation rates. The number of embryos transferred, number of embryos cryopreserved, and implantation and miscarriage rates were similar between the groups. CONCLUSION: PL does not appear to have a negative impact on ongoing PR in our oocytedonation programme.