Modulating Motor Behaviors by Electrical Stimulation of Specific Nuclei in Pigeons
Modulating Motor Behaviors by Electrical Stimulation of Specific Nuclei in Pigeons
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通过电刺激鸽子的特定核来调节运动行为
DOI：
10.1016/s1672-6529(14)60145-1
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发表时间：
2015-10-01
影响因子：
4
通讯作者：
Tang, Yezhong
中科院分区：
文献类型：
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作者：
Cai, Lei;Dai, Zhendong;Tang, Yezhong
白鸽（Columba livia）具有出色的飞行和定向能力，是生物学家研究调节飞行并让鸟类找到回家路的潜在神经机制的理想研究对象。这些机制也吸引了工程师谁想要应用鸽子运动的飞行机器人的设计。在这里，我们确定了运动相关的脑核团，并揭示了它们在空间分布的关系，在轻麻醉和自由移动的鸽子。条件分别。扑翼和侧向身体运动时，成功地引起了电微刺激施加到间脑，中脑的内侧部分，和延髓的轻度麻醉鸽子（N=28），其头部被固定。刺激不同核团和行为的电流阈值范围为10 μ A至20 μ A。在自由移动测试期间（N = 24），通过植入特定核团或脑区的微电极由无线刺激器诱导起飞和转向。结果表明，电刺激这些核团引起了所需的运动行为。此外，在鸽子的运动相关区域和核团中确定了调节机制。不同区域的刺激引起的行为重叠表明复杂的神经网络调节运动行为。因此，需要进行更多的研究，涉及在参与网络的核团内的多个点同时刺激。
Pigeons (Columba livia) have excellent flying and orienting abilities and are ideal study subjects for biologists who research the underlying neurological mechanisms that modulate flying and allow birds to find their way home. These mechanisms also attract the engineers who want to apply pigeon locomotion to the design of flying robots. Here, we identified the motor-related brain nuclei and revealed their relationship in spatial distribution in pigeons under light anesthesia and freely moving. conditions respectively. Flapping and lateral body movements were successfully elicited when electrical microstimulation was applied to the diencephalon, medial part of the midbrain, and medulla oblongata of lightly anesthetized pigeons (N=28) whose heads were fixed. The current thresholds for stimulating different nuclei and behavior ranged from 10 mu A to 20 mu A. During freely moving tests (N = 24), taking off and turning were induced by a wireless stimulator through microelectrodes implanted in specific nuclei or brain regions. The results showed that electrical stimulation of these nuclei elicited the desired motor behavior. In addition, regulatory mechanisms were identified in the motor-related regions and nuclei of pigeons. Overlapping in the behavior elicited by stimulation of different regions indicates that complicated neural networks regulate motor behavior. Therefore, more studies need to be conducted involving simultaneous stimulation at multiple points within the nuclei involved in the networks.