The human brain is intrinsically organized into dynamic, anticorrelated functional networks
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
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DOI：
10.1073/pnas.0504136102
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发表时间：
2005-07-05
影响因子：
11.1
通讯作者：
Raichle, ME
中科院分区：
文献类型：
--
作者：
Fox, MD;Snyder, AZ;Raichle, ME
在执行需要注意力的认知任务时，大脑的某些区域通常会增加活动，而其他区域则会减少活动。在这项研究中，我们调查在何种程度上这一任务相关的二分法是代表内在的休息人脑通过检查的功能性MRI血氧水平依赖信号的自发波动。我们确定了两个截然相反的，广泛分布的大脑网络的基础上，每个网络内的自发相关性和网络之间的相互关系。一个网络由经常表现出任务相关激活的区域组成，另一个网络由经常表现出任务相关失活的区域组成。这种内在的组织，在没有明显的任务表现的情况下，表现出与大脑相关的网络的存在，提供了一个理解大脑功能的关键背景。我们认为，任务驱动的神经元反应和行为都反映了这种动态的、持续的、功能性的大脑组织。
During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of spontaneous fluctuations in the functional MRI blood oxygen level-dependent signal. We identify two diametrically opposed, widely distributed brain networks on the basis of both spontaneous correlations within each network and anticorrelations between networks. One network consists of regions routinely exhibiting task-related activations and the other of regions routinely exhibiting task-related deactivations. This intrinsic organization, featuring the presence of anticorrelated networks in the absence of overt task performance, provides a critical context in which to understand brain function. We suggest that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain.