Healing of localized gingival recessions treated with coronally advanced flap alone or combined with either a resorbable collagen matrix or subepithelial connective tissue graft. A preclinical study
Healing of localized gingival recessions treated with coronally advanced flap alone or combined with either a resorbable collagen matrix or subepithelial connective tissue graft. A preclinical study
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DOI：
10.1007/s00784-014-1299-x
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发表时间：
2015-05-01
影响因子：
3.4
通讯作者：
Iglhaut, Gerhard
中科院分区：
文献类型：
--
作者：
Sculean, Anton;Mihatovic, Ilja;Iglhaut, Gerhard
为了从组织学上评价猪源性胶原基质（CM）和上皮下结缔组织移植物（CTG）用于局部牙龈凹陷覆盖的有效性，在6只比格犬的犬齿颊侧和上下颌的第三和第四前磨牙处创建慢性单米勒I类凹陷。缺损随机采用（1）冠状动脉推进皮瓣手术（CAF）+ CM，（2）CAF + CTG，或（3）CAF单独治疗。在12周时，进行组织测量，例如，参考点（N）-牙龈缘（GM）-和邻近软组织的外轮廓（牙龈厚度[GT]）之间的距离。所有动物的术后愈合均顺利。在整个研究期间，未观察到过敏反应、腹泻或感染等并发症。所有三种治疗方法均覆盖了局部牙龈退缩。组织学分析未能鉴定出CM或CTG的任何残留物。组织学测量显示所有三组的N-GM和GT值结果相当（CAF + CM：1.04 +/- 0.69 mm/0.68 +/- 0.33 mm; CAF + CTG：1.15 +/- 1.12 mm/0.76 +/- 0.37 mm; CAF：1.43 +/- 0.45 mm/0.79 +/- 0.24 mm）。在所使用的缺损模型中，CTG或CM联合CAF的应用与单独使用CAF相比并没有优势。单独使用CAF是治疗局部米勒I类凹陷的有价值的选择。
To histologically evaluate the effectiveness of a porcine derived collagen matrix (CM) and a subepithelial connective tissue graft (CTG) for coverage of localized gingival recessions.Chronic single Miller Class I-like recessions were created at the buccal at the canines and at the third and fourth premolars in the upper and lower jaws of six beagle dogs. The defects were randomly treated with (1) coronally advanced flap surgery (CAF) + CM, (2) CAF + CTG, or (3) CAF alone. At 12 weeks, histometric measurements were made, e.g., between a reference point (N) - and the gingival margin (GM) - and the outer contour of the adjacent soft tissue (gingival thickness [GT]).The postoperative healing was uneventful in all animals. No complications such as allergic reactions, abscesses or infections were noted throughout the entire study period. All three treatments resulted in coverage of localized gingival recessions. The histological analysis failed to identify any residues of CM or CTG. The histometric measurements revealed comparable outcomes for N-GM and GT values for all three groups (CAF + CM: 1.04 +/- 0.69 mm/0.68 +/- 0.33 mm; CAF + CTG: 1.15 +/- 1.12 mm/0.76 +/- 0.37 mm; CAF: 1.43 +/- 0.45 mm/0.79 +/- 0.24 mm).In the used defect model, the application of CTG or CM in conjunction with CAF did not have an advantage over the use of CAF alone.The use of CAF alone is a valuable option for the treatment localized Miller Class I recessions.