Perfluorinated compounds in human milk from Massachusetts, USA
Perfluorinated compounds in human milk from Massachusetts, USA
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DOI：
10.1021/es702789k
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发表时间：
2008-04-15
影响因子：
11.4
通讯作者：
Butenhoff, John L.
中科院分区：
文献类型：
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作者：
Tao, Lin;Kannan, Kurunthachalam;Butenhoff, John L.
据报告，全氟化合物（PFCs），特别是全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）在人体血液中存在。此外，新生儿血液中存在全氟化学品，加上需要研究全氟化学品接触与新生儿出生结果之间的潜在联系，这表明需要确定婴儿接触的来源和程度。在这项研究中，对2004年从美国马萨诸塞州采集的45份母乳样本中的9种全氟辛烷磺酸和全氟辛酸进行了测量。全氟辛烷磺酸和全氟辛酸是主要的全氟辛烷磺酸，平均浓度分别为131皮克/毫升和43.8皮克/毫升。将母乳中全氟辛烷磺酸与全氟辛酸的比例与公布的美国女性血清中的比例进行比较，表明全氟辛酸优先分配到母乳中。第一次哺乳的母亲（n = 34）的乳汁中的全氟辛酸浓度明显高于先前哺乳的母亲（n = 8）。根据估计的体重和牛奶摄入量，婴儿的全氟化学品总平均日摄入量和最高日摄入量分别为23.5和87.1纳克/千克体重。我们发现，PFOS和PFOA的每日摄入量未超过英国建议的每日可耐受摄入量。食品标准局。这是第一项测量美国母乳中PFC含量的研究。
Perfluorinated compounds (PFCs), notably perfluorooctane-sulfonate (PFOS) and perfluorooctanoic acid (PFOA), have been reported in human blood. Furthermore, the occurrence of PFCs in the blood of newborn babies, coupled with the need to study the potential association of PFC exposure with birth outcomes in neonates, suggests the need for determining the sources and magnitude of exposure in infants. In this study, nine PFCs were measured in 45 human breast milk samples collected in 2004 from Massachusetts, U.S.A. PFOS and PFOA were the predominant PFCs found at mean concentrations of 131 and 43.8 pg/mL, respectively. Comparison of the ratio of PFOS to PFOA in human milk with the ratios published for human serum from the U.S. female population suggested preferential partitioning of PFOA to milk. Concentrations of PFOA were significantly higher in the milk of mothers nursing for the first time (n = 34) than in the milk of mothers who have previously nursed (n = 8). Based on the estimated body weight and milk intake, the average and highest daily intakes of total PFCs by infants were 23.5 and 87.1 ng/kg bw, respectively. We found that the daily ingestion rates of PFOS and PFOA did not exceed the tolerable daily intake recommended by the U.K. Food Standards Agency. This is the first study to measure the occurrence of PFCs in human milk from the U.S.A.