Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate
Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate
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DOI：
10.1089/thy.2007.0266
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发表时间：
2008-02-01
期刊：
影响因子：
6.6
通讯作者：
Kim, Brian
中科院分区：
文献类型：
--
作者：
Kim, Brian
长期以来，人们一直认为甲状腺激素是整体能量消耗和基础代谢率的重要决定因素。事实上，调节产热是成年人甲状腺激素的主要任务之一。大量的数据已经证明了甲状腺激素对涉及能量消耗的细胞过程的影响，然而尽管有这样的工作，仍然不清楚哪种3，3 '-三碘甲腺原氨酸响应的能量过程与基础代谢率的确定最相关。最近，一种新的甲状腺激素的代谢作用已被确认的基础上观察到，胆汁酸可以激活局部生产的甲状腺激素通过诱导2型脱碘酶。然而，在完全解释甲状腺激素如何决定代谢率之前，还必须做更多的工作。
It has long been accepted that thyroid hormone is an important determinant of overall energy expenditure and the basal metabolic rate. Indeed, regulating thermogenesis is one of the major tasks of thyroid hormone in adult humans. A wealth of data have demonstrated the effects of thyroid hormone on cellular processes involved with energy expenditure, yet in spite of this body of work it remains unclear which 3,3 '-triiodothyronine-responsive energetic processes are most relevant for the determination of the basal metabolic rate. Recently, a novel metabolic role for thyroid hormone has been recognized based on the observation that bile acids can activate local production of thyroid hormone via induction of the type 2 deiodinase. Nevertheless, more work must be done before it can be fully explained how thyroid hormone determines the metabolic rate.