ACTIVE IODIDE TRANSPORT ACROSS THE PLACENTA OF THE GUINEA-PIG, RABBIT AND RAT
ACTIVE IODIDE TRANSPORT ACROSS THE PLACENTA OF THE GUINEA-PIG, RABBIT AND RAT
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DOI：
10.1113/jphysiol.1956.sp005529
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发表时间：
1956-01-01
影响因子：
5.5
通讯作者：
SCOTT, RF
中科院分区：
文献类型：
--
作者：
LOGOTHETOPOULOS, J;SCOTT, RF
131被皮下注射到怀孕的豚鼠和怀孕的家兔，事先注射或不注射丙硫脲嘧啶。70-80分钟后测定胎儿和母体血浆中的放射性浓度，并以（胎儿/母体）血浆（F/M） I131比值表示。当母体循环中的I131浓度处于上升或稳定水平时，这些比率被发现为1.5-5。注射硫氰酸钠（NaCNS）后，发现（F/M） 131比小于1。怀孕大鼠的（F/M） I131比值不显著高于正常大鼠，但只有注射NaCNS的大鼠的比值在0.3 ~ 0.4之间。胎儿和母体血浆中的I131以游离碘离子的形式存在。碘的胎盘运输机制，抑制硫氰酸盐，是假设。
131 was injected subcutaneously into pregnant guinea-pigs and pregnant rabbits with and without a preceding propylthiouracil injection. Radioactivity concentrations were measured in the foetal and maternal plasmas 70-80 minutes later, and expressed as a (foetal/maternal) plasma (F/M) I131 ratio. These ratios were found to be 1.5-5 at a time when the I131 concentrations in the maternal circulation were on a rising or steady level. After injection of sodium thiocyanate (NaCNS) the (F/M) 131 ratios found were less than unity. In pregnant rats the (F/M) I131 ratios are not significantly higher than unity, but ratios of 0.3 - 0.4 only were found in animals injected with NaCNS. The I131 in foetal and maternal plasma was shown to be present as the free iodide ion. A placental transport mechanism for iodide, inhibited by thiocyanate, is postulated.