Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis
Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis
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DOI：
10.1039/c4cc02014f
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发表时间：
2014-01-01
影响因子：
4.9
通讯作者：
Ohshima, Takashi
中科院分区：
文献类型：
--
作者：
Shimizu, Yuhei;Noshita, Megumi;Ohshima, Takashi
添加铵盐可显著加速未活化酰胺键的肼解。反应在50-70 ℃下进行，得到具有宽底物范围的胺，其优于现有的酰胺键裂解反应。肽和氨基糖衍生物的应用程序也被证明。
Hydrazinolysis of unactivated amide bonds is significantly accelerated by the addition of ammonium salts. The reactions proceed at 50-70 degrees C to give amines with broad substrate scope that outperforms existing amide bond cleavage reactions. Application to peptide and amino sugar derivatives is also demonstrated.