Associations of Ambient Air Pollution with Chronic Obstructive Pulmonary Disease Hospitalization and Mortality
Associations of Ambient Air Pollution with Chronic Obstructive Pulmonary Disease Hospitalization and Mortality
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DOI：
10.1164/rccm.201211-2004oc
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发表时间：
2013-04-01
影响因子：
24.7
通讯作者：
Brauer, Michael
中科院分区：
文献类型：
--
作者：
Gan, Wen Qi;FitzGerald, J. Mark;Brauer, Michael
理论基础：环境空气污染已被认为是慢性阻塞性肺疾病(COPD)的危险因素。目的：探讨长期暴露于与交通相关的空气污染和木烟污染与COPD住院和死亡风险的关系。方法：这项基于人群的队列研究包括5年暴露期和4年随访期。所有在暴露期间居住在加拿大温哥华大都市的45-85岁的居民在基线时没有COPD的知识都被纳入了这项研究(n=467,994)。居民暴露于与交通有关的空气污染物(黑碳、颗粒物)
Rationale: Ambient air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD). However, there is a lack of longitudinal studies to support this assertion.Objectives: To investigate the associations of long-term exposure to elevated traffic-related air pollution and woodsmoke pollution with the risk of COPD hospitalization and mortality.Methods: This population-based cohort study included a 5-year exposure period and a 4-year follow-up period. All residents aged 45-85 years who resided in Metropolitan Vancouver, Canada, during the exposure period and did not have known COPD at baseline were included in this study (n = 467,994). Residential exposures to traffic-related air pollutants (black carbon, particulate matter