Increased corticospinal excitability during direct observation of self-movement and indirect observation with a mirror box
Increased corticospinal excitability during direct observation of self-movement and indirect observation with a mirror box
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DOI：
10.1016/j.neulet.2007.04.025
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发表时间：
2007-05-29
影响因子：
2.5
通讯作者：
Kasai, Tatsuya
中科院分区：
文献类型：
--
作者：
Funase, Kozo;Tabira, Takayuki;Kasai, Tatsuya
为了探讨基于初级运动皮层镜像神经元（MN）系统的镜像盒疗法的效果，我们研究了直接（无镜子）和间接（有镜子）观察健康受试者的自我运动是否会引起经颅磁刺激（TMS）诱发的运动诱发电位（MEP）的变化。mep来自第一背骨间肌（FDI）和桡侧腕屈肌（FCR）。观察自我运动时的体感诱发电位（SEPs）。在有和没有镜子的情况下，自我运动的观察结果都增加了MEP振幅。此外，MEP振幅的增加是与观察到的运动有关的原动机肌肉特有的。在有镜子和没有镜子的自我运动观察中，SEPs的增加与MEPs相似。我们得出的结论是，尽管MN系统可以通过观察自我运动来激活，其方式与观察他人运动的方式相似，但对皮质脊髓兴奋性没有可检测到的影响，这是通过镜子观察到的运动所特有的。2007爱思唯尔爱尔兰有限公司版权所有。
To explore the effect of mirror box therapy based on the mirror neuron (MN) system of the primary motor cortex (M1), we examined if direct (without a mirror) and indirect (with a mirror) observation of self-movement in healthy subjects induced changes in motor evoked potential (MEP) evoked by transcranial magnetic stimulation (TMS). MEPs were elicited from the first dorsal interosseous (FDI) and the flexor carpi radialis (FCR) muscles. Somatosensory evoked potentials (SEPs) during self-movement observation were also recorded. Both observations of self-movement with and without a mirror increased MEP amplitude. In addition, increase in MEP amplitude was specific to the prime mover muscle involved in the observed movement. The SEPs increased similar to the MEPs during both observations of self-movement with and without a mirror. We conclude that although the MN system can be activated by observing self-movement in a manner similar to that achieved by observing movement of another person, there were no detectable effect on corticospinal excitability that were specific to movements observed with a mirror. (c) 2007 Elsevier Ireland Ltd. All rights reserved.