On-chip thermopneumatic pressure for discrete drop pumping
On-chip thermopneumatic pressure for discrete drop pumping
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DOI：
10.1021/ac000711f
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发表时间：
2001-04-15
影响因子：
7.4
通讯作者：
Burns, MA
中科院分区：
文献类型：
--
作者：
Handique, K;Burke, DT;Burns, MA
一类“芯片实验室”设备使用外部气压来泵送微通道网络中的离散液滴。外部空气接头可能会很笨重，而且会占用大量空间。我们已经开发了一种芯片技术来产生测量和泵送纳升体积离散液滴所需的压力。这是通过加热产生压力室中的滞留空气来实现的，产生压力室通过空气输送通道连接到液体输送微通道中的加压点。被困的风量约为100nL，由阻性金属加热器加热数十摄氏度，产生约7.5kN/m(2)的空气压力。在微通道装置中，通过控制空气加热速率来电子控制离散液滴泵浦的速率。在微通道(300微米×30微米)中，空气腔以类似于6度C/S的速率加热，可获得20nL/S数量级的流量。本文描述了用于测量和抽运微通道中的纳升离散液滴的这种产生片上气压的新技术的设计、制造和操作。
A class of "lab-on-a-chip" devices use external air pressure for pumping discrete drops in a microchannel network. External air connectors can be cumbersome and are real-estate intensive. We have developed an on-chip technique to generate pressures required for metering and pumping of nanoliter-volume discrete drops. This is achieved by heating of trapped air in a pressure-generating chamber, The pressure-generating chamber is connected to the point of pressure application in the liquid-conveying microchannel through an air-delivery channel. The trapped air volume on the order of 100 nL is heated by resistive metal heaters by tens of degrees celcius to generate air pressures on the order of 7.5 kN/m(2). The rate of discrete drop pumping is electronically controlled in the microchannel device by controlling the rate of air heating. Flow rates on the order of 20 nL/s are obtained in the microchannel (300 mum x 30 mum) by heating the air chamber at the rate of similar to6 degreesC/s. In this paper, we describe the design, fabrication, and operation of this new technique of generating on-chip air pressure, used for metering and pumping nanoliter discrete drops in microchannels.