Doxorubicin-loaded nanoscale metal-organic framework for tumor-targeting combined chemotherapy and chemodynamic therapy
Doxorubicin-loaded nanoscale metal-organic framework for tumor-targeting combined chemotherapy and chemodynamic therapy
复制标题
用于肿瘤靶向联合化疗和化学动力学治疗的负载阿霉素的纳米级金属有机框架
DOI：
10.1039/c9bm01044k
复制
发表时间：
2019-11-01
影响因子：
6.6
通讯作者：
Zhang, Yingchao
中科院分区：
文献类型：
--
作者：
Xue, Ting;Xu, Caina;Zhang, Yingchao
阿霉素（DOX）作为传统的化疗药物，由于其疗效差、毒副作用大，限制了其在临床上的应用。本文采用微波辅助合成法制备了金属有机骨架MIL-100，并将DOX负载于MIL-100中，然后在MIL-100表面修饰透明质酸（HA）得到DMH纳米粒。DMH纳米粒具有以下优点：（1）MIL-100可作为药物载体，具有较高的DOX负载效率; MIL-100还可在H2 O2存在下通过类Fenton反应产生羟基自由基（OH），用于化学动力学治疗（CDT）。(2)为了提高MIL-100的生物学活性，将HA修饰在MIL-100表面，使其具有对肿瘤组织的靶向性。(3)DMH纳米粒可通过联合化疗和化学动力学治疗，增强抗肿瘤疗效，降低药物相关毒性。DMH纳米粒作为降低乳腺癌全身毒性和提高治疗效果的候选药物具有巨大的潜力。
Doxorubicin (DOX) as a traditional chemotherapy drug is restricted in clinical applications due to its poor therapeutic activity and severe side effects. Herein, we prepared a metal-organic framework (MOF) MIL-100 by a microwave-assisted synthesis and DOX was loaded in MIL-100 and then, hyaluronic acid (HA) was modified on the surface of MIL-100 to give DMH NPs. The DMH NPs possessed the following advantages: (1) MIL-100 could serve as a drug carrier with a high DOX loading efficiency; MIL-100 could also generate a hydroxyl radical (OH) in the presence of H2O2 for chemodynamic therapy (CDT) via a Fenton-like reaction. (2) To improve the dispersibility of MIL-100, HA was modified on the surface of MIL-100, which could endow MIL-100 with a targeting ability towards tumor tissues. (3) DMH NPs could enhance antitumor efficacy and reduce drug-related toxicity though the combination of chemotherapy and chemodynamic therapy. DMH NPs have enormous potential as a candidate for reducing the systemic toxicity and improving the treatment effect for breast cancer.