Specific immunoglobulin A-secreting cells in peripheral blood of humans following oral immunization with a bivalent Salmonella typhi-Shigella sonnei vaccine or infection by pathogenic S. sonnei
Specific immunoglobulin A-secreting cells in peripheral blood of humans following oral immunization with a bivalent Salmonella typhi-Shigella sonnei vaccine or infection by pathogenic S. sonnei
复制标题
口服二价伤寒沙门氏菌-宋内志贺氏菌疫苗或致病性宋内氏志贺氏菌感染后，人类外周血中特异性免疫球蛋白 A 分泌细胞
作者：
L. L. Van De Verg;D. Herrington;J. Murphy;S. Wasserman;S. B. Formal;M. M. Levine
通过检测外周血中肠道来源的运输抗体分泌细胞 (ASC) 来评估二价伤寒沙门氏菌-宋内志贺氏菌疫苗株 5076-1C 刺激人体肠道免疫球蛋白 A 反应的能力。接种疫苗后，分别在 13 名疫苗接种者中的 10 名和 13 名疫苗接种者中观察到对伤寒沙门氏菌和宋内氏沙门氏菌 O 抗原的免疫球蛋白 A-ASC 反应。在所有出现临床疾病的受试者中，用致病性宋内链球菌进行的实验激发了 ASC 对宋内链球菌 O 抗原的反应。 ASC 对攻击的反应程度明显大于疫苗接种产生的反应程度。此外，与未免疫对照的反应相比，先前用5076-1C免疫的个体在用S. sonnei攻击后表现出显着更强的ASC反应。
The ability of bivalent Salmonella typhi-Shigella sonnei vaccine strain 5076-1C to stimulate an intestinal immunoglobulin A response in humans was evaluated by detecting gut-derived, trafficking antibody-secreting cells (ASC) in peripheral blood. Following vaccination, an immunoglobulin A-ASC response to O antigens of S. typhi and S. sonnei was observed in 10 of 13 and 13 of 13 vaccine recipients, respectively. Experimental challenge with pathogenic S. sonnei stimulated an ASC response to the S. sonnei O antigen in all subjects who developed clinical illness. The magnitude of the ASC response to challenge was significantly greater than that resulting from vaccination. Furthermore, compared with the response of the unimmunized controls, individuals previously immunized with 5076-1C demonstrated a significantly greater ASC response following challenge with S. sonnei.