Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma.
Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma.
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DOI：
10.1186/1475-2867-14-33
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发表时间：
2014
影响因子：
5.8
通讯作者：
Guo L
中科院分区：
文献类型：
--
作者：
Yang J;Huang J;Luo L;Chen Z;Guo Y;Guo L
PRO2000/ANCCA可能是位于8q染色体区域的一个重要候选基因。然而，它的重要性仍不清楚。本研究旨在探讨PRO2000/ANCCA在肝细胞癌中的表达及其临床意义。分析PRO2000/ANCCA表达与肝细胞癌临床病理因素及预后的关系。应用免疫组织化学方法检测107例肝癌组织及癌旁组织中PRO2000/ANCCA、Ki-67、细胞周期蛋白D1、p53和p21的表达。在107例肝细胞癌组织中，66例(64.94%)表达PRO2000/ANCCA，其中高分化肿瘤36例(47.37%)，低分化肿瘤30例(96.77%)，癌旁非肿瘤组织中8例(7.48%)有散在阳性细胞。PRO2000/ANCCA的表达与肿瘤组织分化程度、肿瘤结节数、TNM分期、肿瘤微卫星、门静脉癌栓及复发有关，而与性别、年龄、肿瘤大小、肝硬变、乙肝病毒感染及血清甲胎蛋白水平无关。在肝细胞癌中，PRO2000/ANCCA与Ki-67、CyclinD1的表达密切相关。PRO2000/ANCCA免疫阳性与p53和p21WAF1/Cip1无关。PRO2000/ANCCA的高表达与肝细胞癌患者的不良预后相关，是肝细胞癌预后不良的预测指标。PRO2000/ANCCA可能参与了肝细胞癌的发生发展，并可能通过非依赖于p53/P21WAF1/Cip1的途径促进细胞增殖。
PRO2000/ANCCA may be an important candidate gene which located within a region of chromosome 8q in hepatocellular carcinoma (HCC). However, its significance remains unclear. The aim of this study was to explore the clinical significance of PRO2000/ANCCA expression in HCC. The correlations of PRO2000/ANCCA expression with clinicopathological factors and prognosis of HCC patients were analyzed. Expression of PRO2000/ANCCA, ki-67, cyclinD1, p53 and p21 was detected in HCCs from 107 patients along with corresponding non-tumor tissues by immunohistochemistry. PRO2000/ANCCA expression was present in 66 of 107 (64.94%) HCC specimens in which 36 of 76 (47.37%) in well differentiated tumors and 30 of 31 (96.77%) in poorly differentiated tumors respectively, while 8 (7.48%) in adjacent non-tumor tissues with scattered positive cells. PRO2000/ANCCA expression was associated with clinicopathological features such as histological differentiation, number of tumor nodules, TNM stage, tumor microsatellite, portal vein tumor thrombus and recurrence, but not with gender, age, tumor size, cirrhosis, HBV infection and serum fetoprotein (AFP) level. There was a close relationship between PRO2000/ANCCA and ki-67 and cyclinD1 in HCC. PRO2000/ANCCA immunopositivity was independent of p53 and p21WAF1/Cip1. Increased expression of PRO2000/ANCCA is associated with adverse outcome in patients with HCC and is a predictor of poor prognosis for HCC. PRO2000/ANCCA may be involved in the development of HCC and might promote cell proliferation through a p53/ P21WAF1/Cip1-independent pathway.
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影响因子：
64.5
作者：
ELDEIRY, WS;TOKINO, T;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
影响因子：
3.7
作者：
NODA, A;NING, Y;SMITH, JR
通讯作者：
SMITH, JR
影响因子：
3.7
作者：
Zhang, Yang;Sun, Yihua;Ji, Hongbin
通讯作者：
Ji, Hongbin
影响因子：
8
作者：
Caron, C.;Lestrat, C.;Khochbin, S.
通讯作者：
Khochbin, S.
影响因子：
4
作者：
Gladden, AB;Diehl, JA
通讯作者：
Diehl, JA