The suppression of a selfish genetic element increases a male's mating success in a fly.
The suppression of a selfish genetic element increases a male's mating success in a fly.
复制标题
DOI：
10.1002/ece3.10719
复制
发表时间：
2023-11
影响因子：
2.6
通讯作者：
Verspoor, Rudi L.
中科院分区：
文献类型：
--
作者：
Lyth, Sophie;Betancourt, Andrea J.;Price, Tom A. R.;Verspoor, Rudi L.
X染色体减数分裂驱动（XCMD）在精子发生过程中杀死携带Y的精子，导致自私X染色体的偏向传递。尽管传播如此强烈，一些天然 XCMD 系统仍保持较低且稳定的频率，而不是在人群中快速传播。原因可能是男性携带者的健康状况可能会下降，因为他们失去了一半的精子，只能生育女儿，并且可能携带与 XCMD 相关的有害等位基因。因此，雌性可能会受益于避免与雄性携带者交配，从而导致健康状况进一步下降。 XCMD 的基因抑制因子也很常见，可以阻止 Y 精子被杀死并恢复公平的孟德尔遗传，并且可以防止 XCMD 的传播。然而，受到抑制的雄性是否与野生型雄性一样健康仍然是一个悬而未决的问题，因为基因抑制基因可能对雄性交配成功的影响很少被考虑。在这里，我们研究了果蝇中 XCMD 雄性和抑制 XCMD 雄性与野生型雄性果蝇的交配能力，在果蝇发生的野生种群中，驱动力保持在 20% 的稳定频率。我们使用竞争性和非竞争性交配试验来评估该系统中雄性交配的成功率。我们没有发现任何证据表明未抑制的 XCMD 男性受到歧视。然而值得注意的是，与野生型对照相比，其抑制的 XCMD 对应物具有更高的雄性交配成功率。与野生型雄性相比，未抑制 XCMD 的雄性后代产量降低了 12%。该成本似乎太弱，无法抵消 XCMD 的传输优势，因此阻止 XCMD 传播的因素仍不清楚。我们研究了 SR、抑制 SR 和野生型雄性的交配能力。我们发现携带 SR 抑制基因的雄性交配成功率更高。我们还发现，SR 在后代产量减少方面遭受了适应性成本。
X chromosome meiotic drive (XCMD) kills Y‐bearing sperm during spermatogenesis, leading to the biased transmission of the selfish X chromosome. Despite this strong transmission, some natural XCMD systems remain at low and stable frequencies, rather than rapidly spreading through populations. The reason may be that male carriers can have reduced fitness, as they lose half of their sperm, only produce daughters, and may carry deleterious alleles associated with XCMD. Thus, females may benefit from avoiding mating with male carriers, yielding a further reduction in fitness. Genetic suppressors of XCMD, which block the killing of Y sperm and restore fair Mendelian inheritance, are also common and could prevent the spread of XCMD. However, whether suppressed males are as fit as a wild‐type male remains an open question, as the effect that genetic suppressors may have on a male's mating success is rarely considered. Here, we investigate the mating ability of XCMD males and suppressed XCMD males in comparison to wild‐type males in the fruit fly Drosophila subobscura, where drive remains at a stable frequency of 20% in wild populations where it occurs. We use both competitive and non‐competitive mating trials to evaluate male mating success in this system. We found no evidence that unsuppressed XCMD males were discriminated against. Remarkably, however, their suppressed XCMD counterparts had a higher male mating success compared to wild‐type controls. Unsuppressed XCMD males suffered 12% lower offspring production in comparison to wild‐type males. This cost appears too weak to counter the transmission advantage of XCMD, and thus the factors preventing the spread of XCMD remain unclear. We investigated the mating ability of SR, suppressed SR, and wild‐type males. We found that males that carried a suppressor against SR had higher mating success. We also found that SR suffered a fitness cost in terms of reduced offspring production.
登录
查看更多内容
影响因子：
10.7
作者：
Bastide, Heloise;Cazemajor, Michel;Montchamp-Moreau, Catherine
通讯作者：
Montchamp-Moreau, Catherine
影响因子：
9.8
作者：
Hornett EA;Charlat S;Duplouy AM;Davies N;Roderick GK;Wedell N;Hurst GD
通讯作者：
Hurst GD
影响因子：
3.3
作者：
通讯作者：
--
DOI：
10.1073/pnas.0608184103
发表时间：
2006-10-31
影响因子：
11.1
作者：
Byers, John A.;Waits, Lisette
通讯作者：
Waits, Lisette
影响因子：
3.3
作者：
Holman, Luke;Freckleton, Robert P.;Snook, Rhonda R.
通讯作者：
Snook, Rhonda R.