Catalytic Asymmetric Synthesis of Highly Substituted Pyrrolizidines.
Catalytic Asymmetric Synthesis of Highly Substituted Pyrrolizidines.
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DOI：
10.1039/c2sc21617e
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发表时间：
2012-11-13
期刊：
影响因子：
8.4
通讯作者：
Reisman SE
中科院分区：
文献类型：
--
作者：
Lim AD;Codelli JA;Reisman SE
发展了催化不对称双（1，3）偶极环加成反应。使用手性银催化剂，可以在一个烧瓶中由廉价的市售原料制备对映体富集的吡咯烷。吡咯里西啶产物含有多种取代模式和多达六个立体中心。
A catalytic asymmetric double (1,3)-dipolar cycloaddition reaction has been developed. Using a chiral silver catalyst, enantioenriched pyrrolizidines can be prepared in one flask from inexpensive, commercially available starting materials. The pyrrolizidine products contain a variety of substitution patterns and as many as six stereogenic centers.