Stoffwechselprodukte von Mikroorganismen 73. Mitteilung [1] Chlorothricin und Des‐chlorothoricin
Stoffwechselprodukte von Mikroorganismen 73. Mitteilung [1] Chlorothricin und Des‐chlorothoricin
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73. Mitteilung [1] 氯丝菌素和脱氯丝菌素
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
H. Zähner
中科院分区：
文献类型：
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作者：
W. Keller;R. Muntwyler;W. Pache;H. Zähner
从一株抗生素链霉菌中分离出氯三氯霉素和去氯三氯霉素的结晶混合物。通过降解分离得到5-氯-6-甲基水杨酸甲醚（氯三甲苷）和6-甲基水杨酸甲醚（去氯三甲苷）。这两种抗生素的常见降解产物是2-脱氧-d -鼠李糖和一种结构未知的苷元C30H38O8。抗生素混合物在合成培养基上对革兰氏阳性菌有活性，但在复合培养基上无活性。
A crystalline mixture of the antibiotics chlorothricin and dechlorothricin was isolated from a strain of Streptomyces antibioticus. By degradation 5-chloro-6-methylsalicylic acid methyl ether (from chlorothricin) and 6-methylsalicylic acid methyl-ether (from dechlorothricin) were isolated. Common degradation products of both antibiotics were 2-deoxy-D-rhamniose and an aglycone, C30H38O8, of unknown structure. The antibiotic mixtures was active against GRAM positive bacteria on syntheitc, but not on complex media.