Comparisons of polybrominated diphenyl ethers levels in paired South Korean cord blood, maternal blood, and breast milk samples
Comparisons of polybrominated diphenyl ethers levels in paired South Korean cord blood, maternal blood, and breast milk samples
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DOI：
10.1016/j.chemosphere.2011.11.074
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发表时间：
2012-03-01
期刊：
影响因子：
8.8
通讯作者：
Kim, Hyung Sik
中科院分区：
文献类型：
--
作者：
Kim, Tae Hyung;Bang, Du Yeon;Kim, Hyung Sik
多溴联苯醚（PBDEs）是一种常用的阻燃剂，已被报道为潜在的内分泌干扰物和神经发育毒物，从而引起公众健康问题。本研究的目的是调查韩国脐带血、母亲血液和母乳中多溴二苯醚浓度之间的关系。我们评估了脐带血、孕妇血和母乳配对样本中的多溴联苯醚水平。2008年，在第一妇女医院（韩国首尔）采集的21个配对样本中测量了七种多溴二苯醚同系物的含量。我们还测量了孕妇和脐带血中的甲状腺激素水平，以评估多溴二苯醚暴露与甲状腺激素水平之间的关系。然而，血清甲状腺素（14）与多溴二苯醚总浓度之间没有相关性。脐带血、母体血液和母乳中的多溴二苯醚总浓度分别为10.7 +/- 5.1纳克/克（-1）脂、7.7 +/- 4.2纳克/克（-1）脂和3.0 +/- 1.8纳克/克（-1）脂。在脐带血中观察到的多溴二苯醚总浓度范围为2.28-30.94纳克/克（-1）脂质，在母体血液中为1.8-17.66纳克/克（-1）脂质，在母乳中为1.08-8.66纳克/克（-1）脂质。据观察，所有样本中主要存在BDE-47（占多溴二苯醚总量的45-73%），其次是BDE-153。母乳和脐带血或母体血液和脐带血样本中的主要溴化二苯醚同系物存在很强的相关性。测量母亲血液或母乳中的多溴联苯醚浓度可能有助于确定婴儿体内的多溴联苯醚浓度。(C)2011爱思唯尔有限公司版权所有。
Polybrominated diphenyl ethers (PBDEs), commonly used flame retardants, have been reported as potential endocrine disruptor and neurodevelopmental toxicants, thus giving rise to the public health concern. The goal of this study was to investigate the relationship between umbilical cord blood, maternal blood, and breast milk concentrations of PBDEs in South Korean. We assessed PBDE levels in paired samples of umbilical cord blood, maternal blood, and breast milk. The levels of seven PBDE congeners were measured in 21 paired samples collected from the Cheil Woman's Hospital (Seoul, Korea) in 2008. We also measured thyroid hormones levels in maternal and cord blood to assess the association between PBDEs exposure and thyroid hormone levels. However, there was no correlation between serum thyroxin (14) and total PBDEs concentrations. The total PBDEs concentrations in the umbilical cord blood, maternal blood, and breast milk were 10.7 +/- 5.1 ng g(-1) lipid, 7.7 +/- 4.2 ng g(-1) lipid, and 3.0 +/- 1.8 ng g(-1) lipid, respectively. The ranges of total PBDE concentrations observed were 2.28-30.94 ng g(-1) lipid in umbilical cord blood, 1.8-17.66 ng g(-1) lipid in maternal blood, and 1.08-8.66 ng g(-1) lipid in breast milk. BDE-47 (45-73% of total PBDEs) was observed to be present dominantly in all samples, followed by BDE-153. A strong correlation was found for major BDE-congeners between breast milk and cord blood or maternal blood and cord blood samples. The measurement of PBDEs concentrations in maternal blood or breast milk may help to determine the concentration of PBDEs in infant. (C) 2011 Elsevier Ltd. All rights reserved.