Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver.
Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver.
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DOI：
10.14670/hh-29.1077
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发表时间：
2014-02
影响因子：
2
通讯作者：
A. Swain;Tomoko Inoue;Keai Sinn Tan;Y. Nakanishi;D. Sugiyama
中科院分区：
文献类型：
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作者：
A. Swain;Tomoko Inoue;Keai Sinn Tan;Y. Nakanishi;D. Sugiyama
胎儿肝脏（FL）是造血干细胞（HSC）扩增和分化的重要结构，但尽管如此，对FL造血发生的确切机制知之甚少。小鼠原始造血在12.5 dpc时让位于确定性造血，这一过程受到许多内在和外在因素的调节。内源性调节是细胞内的过程，已被报道是重要的启动确定性造血。FL内有几种结构参与造血的外部调节，包括成肝细胞和肝窦内皮细胞（LSEC）。成肝细胞和内皮细胞包含参与造血的外部调节的单独的小生境。研究表明，与胎肝基质细胞共培养可以促进红系细胞的扩增，尽管基质细胞这样做的方式仍然未知。了解FL中调节造血的机制可能会产生新型疗法，包括安全可靠地将HSC移植给患有血液和骨髓并发症的患者。本文旨在总结FL内有关造血调节的当前知识状况。
The fetal liver (FL) is an important structure in expansion and differentiation of hematopoietic stem cells (HSC), but despite this little is known about the exact mechanisms in which FL hematopoiesis takes place. Primitive hematopoiesis gives way to definitive hematopoiesis at 12.5 dpc in mice and the process is regulated by a number of intrinsic and extrinsic factors. Intrinsic regulations are intracellular processes that have been reported to be important in the initiation of definitive hematopoiesis. Several structures are involved with extrinsic regulations of hematopoiesis within the FL, including hepatoblasts and liver sinusoidal endothelial cells (LSEC). Hepatoblasts and endothelial cells comprise separate niches involved in the extrinsic regulation of hematopoiesis. Studies have shown that co-cultures with fetal liver stromal cells can promote the expansion of erythroid cells, although the way in which stromal cells do this is still unknown. Understanding the mechanisms in which hematopoiesis is regulated in the FL could lead to the production of novel therapies involving the safe and reliable transplantation of HSCs to patients with blood and bone marrow complications. This review aims to summarize the current state of knowledge about the regulation of hematopoiesis specifically within the FL.