Nectin and afadin: novel organizers of intercellular junctions
Nectin and afadin: novel organizers of intercellular junctions
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DOI：
10.1242/jcs.00167
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发表时间：
2003-01-01
影响因子：
4
通讯作者：
Nakanishi, H
中科院分区：
文献类型：
--
作者：
Takai, Y;Nakanishi, H
钙粘蛋白超家族在细胞间粘附中起关键作用。新兴的细胞间粘附系统由 nectin 和 afadin 组成，在多种细胞间连接的组织中也发挥作用，无论是与钙粘蛋白合作还是独立。 Nectin 是一种不依赖 Ca2+ 的免疫球蛋白样细胞间粘附分子，而 afadin 是一种 nectin 和肌动蛋白丝结合蛋白，可将 nectin 连接到肌动蛋白细胞骨架。这种新型细胞间粘附系统在上皮细胞中基于 E-钙粘蛋白的粘附连接和基于密蛋白的紧密连接的组织中发挥作用。此外，粘附系统还参与神经元突触的形成以及睾丸中支持细胞和精子细胞之间异型连接的组织。
The cadherin superfamily plays key roles in intercellular adhesion. An emerging intercellular adhesion system, consisting of nectin and afadin, also has roles in organization of a variety of intercellular junctions either in cooperation with, or independently of, cadherin. Nectin is a Ca2+-independent immunoglobulin-like intercellular adhesion molecule, and afadin is a nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. This novel intercellular adhesion system has roles in the organization of E-cadherin-based adherens junctions and claudin-based tight junctions in epithelial cells. The adhesion system is furthermore involved in the formation of synapses in neurons and the organization of heterotypic junctions between Sertoli cells and spermatids in the testis.