A study of the genetic variability of human respiratory syncytial virus in Croatia, 2006-2008
A study of the genetic variability of human respiratory syncytial virus in Croatia, 2006-2008
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DOI：
10.1002/jmv.23425
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发表时间：
2012-12-01
影响因子：
12.7
通讯作者：
Tabain, Irena
中科院分区：
文献类型：
--
作者：
Forcic, Dubravko;Ivancic-Jelecki, Jelena;Tabain, Irena
人呼吸道合胞病毒（HRSV）是婴幼儿急性下呼吸道疾病的常见病原体。在克罗地亚HRSV的分子流行病学连续四个赛季（2006年至2008年）进行了调查。从萨格勒布一家儿科诊所的696例筛查病例中共选择了72份HRSV样本。HRSV的分子特征表明，在前两个流行季节，HRSV B组病毒占优势，而在后两个流行季节，HRSV A组病毒占优势。系统发育分析表明，NA 1和BA 9是本研究期间检测到的HRSV流行的主要基因型。总体而言，82.9%的HRSV A株属于NA 1基因型。在2006年和2007年连续两个季节检测到的HRSV B基因型BA 9是主要的HRSV B基因型，占所有HRSV B毒株的80.6%。这项研究提供了在克罗地亚的HRSV基因型和它们的分子特征的循环模式的数据。医学病毒学杂志84：1985 - 1992，2012. (c)2012 Wiley Periodicals，Inc.
Human respiratory syncytial virus (HRSV) is a common etiological agent of acute lower respiratory tract disease in infants. The molecular epidemiology of HRSV in Croatia over four consecutive seasons (from 2006 to 2008) was investigated. A total of 72 HRSV samples were chosen from 696 screened cases in a pediatric clinic in Zagreb. Molecular characterization of HRSV revealed the predominance of HRSV group B viruses in the first two epidemic seasons and HRSV group A viruses in the next two seasons. According to the phylogenetic analysis, NA1 and BA9 were the predominant circulating HRSV genotypes detected during the study. Overall, 82.9% of all HRSV A strains belonged to the NA1 genotype. The HRSV B genotype BA9, detected in two consecutive seasons (2006 and 2007), was the predominant circulating HRSV B genotype, accounting for 80.6% of all HRSV B strains. This study provides data on the circulation pattern of HRSV genotypes in Croatia and their molecular characterization. J. Med. Virol. 84:19851992, 2012. (c) 2012 Wiley Periodicals, Inc.