Factors Associated With Diabetes-Specific Health-Related Quality of Life in Youth With Type 1 Diabetes: The Global TEENs Study
Factors Associated With Diabetes-Specific Health-Related Quality of Life in Youth With Type 1 Diabetes: The Global TEENs Study
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DOI：
10.2337/dc16-1990
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发表时间：
2017-08-01
期刊：
影响因子：
16.2
通讯作者：
Mathieu, Chantal
中科院分区：
文献类型：
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作者：
Anderson, Barbara J.;Laffel, Lori M.;Mathieu, Chantal
我们的目的是在全球1型糖尿病（T1D）青年和年轻成人样本中表征糖尿病特异性健康相关生活质量（D-HRQOL），并确定与生活质量相关的主要因素。研究设计和方法青少年研究是一项国际性的横断面研究，研究对象为8-25岁的青少年，患有T1D。参与者（N=5,887）来自5大洲20个国家的临床站点，分为3个预定年龄组：8-12岁、13-18岁和19-25岁。为了评估D-HRQOL，参与者完成了PedsQL DiabetesModule 3.0，并接受了有关家庭相关因素的访谈。从医疗记录中收集治疗方案和自我管理行为的细节。结果在所有年龄组中，女性报告的D-HRQOL明显低于男性。19-25岁年龄组的D-HRQOL最低。多元线性回归分析显示，D-HRQOL与HbA（1c）显著相关；HbA（1c）越低，D-HRQOL越好。三种糖尿病管理行为与更好的D-HRQOL显著相关：采用先进的方法测量食物摄入量；更频繁的每日血糖监测；每周锻炼30分钟的天数也更多。结论：在所有三个年龄组中，HbA（1c）越低，D-HRQOL越好，这强调了在全球青年和年轻人样本中，更好的D-HRQOL与最佳血糖控制之间的强烈关联。三种糖尿病管理行为也与最佳血糖控制有关，这代表了临床干预改善D-HRQOL和血糖控制的潜在可修改因素。
OBJECTIVEOur objective was to characterize diabetes-specific health-related quality of life (D-HRQOL) in a global sample of youth and young adults with type 1 diabetes (T1D) and to identify the main factors associated with quality of life.RESEARCH DESIGN AND METHODSThe TEENs study was an international, cross-sectional study of youth, 8-25 years of age, with T1D. Participants (N=5,887) were seen in clinical sites in 20 countries across 5 continents enrolled for 3 predetermined age groups: 8-12, 13-18, and 19-25 years of age. To assess D-HRQOL, participants completed the PedsQL DiabetesModule 3.0 and were interviewed about family-related factors. Specifics about treatment regimen and self-management behaviors were collected from medical records.RESULTSAcross all age groups, females reported significantly lower D-HRQOL than did males. The 19-25-year age group reported the lowest D-HRQOL. Multivariate linear regression analyses revealed that D-HRQOL was significantly related to HbA(1c); the lower the HbA(1c), the better the D-HRQOL. Three diabetes-management behaviors were significantly related to better D-HRQOL: advanced methods used to measure food intake; more frequent daily blood glucose monitoring; and more days per week that youth had >= 30 min of physical activity.CONCLUSIONSIn all three age groups, the lower the HbA(1c), the better the D-HRQOL, underscoring the strong association between better D-HRQOL and optimal glycemic control in a global sample of youth and young adults. Three diabetes-management behaviors were also related to optimal glycemic control, which represent potentially modifiable factors for clinical interventions to improve D-HRQOL as well as glycemic control.