Effects of subminimal inhibitory concentrations of antibiotics on adhesiveness of Escherichia coli in vitro.
Effects of subminimal inhibitory concentrations of antibiotics on adhesiveness of Escherichia coli in vitro.
复制标题
抗生素亚最低抑菌浓度对体外大肠杆菌粘附性的影响。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
O. Zak
中科院分区：
文献类型：
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作者：
K. Vosbeck;H. Handschin;E. B. Menge;O. Zak
研究了放射性标记的大肠杆菌（SS 142株）与人上皮样组织培养细胞系肠407单层的粘附。在本试验中，在亚最小抑制浓度的四环素、克林霉素或甲氧苄啶-磺胺甲唑存在下生长的细菌的粘附以剂量依赖性的方式降低。相比之下，在这样的浓度下，萘啶酸增强了这种细菌菌株和其他抗生素的粘附，青霉素G、氨苄青霉素、美西林、头孢西腈、头孢氨苄、头孢噻肟、氯霉素和链霉素对它的耐药性无影响。
The adhesion of radiolabeled Escherichia coli (strain SS142) to monolayers of Intestine 407, a human epithelioid tissue culture cell line, was investigated. In this assay the adhesion of bacteria grown in the presence of subminimal inhibitory concentrations of tetracycline, clindamycin,, or trimethoprim-sulfametrole was reduced in a manner that was dose dependent. In contrast, at such concentrations nalidixic acid enhanced the adhesion of this bacterial strain, and other antibiotics-e.g., penicillin G, ampicillin, mecillinam, cephacetrile, cephalexin, cefotaxime, chloramphenicol, and streptomycin-did not affect its adhesiveness.