Evaluation of the vector competence of a native UK mosquito Ochlerotatus detritus (Aedes detritus) for dengue, chikungunya and West Nile viruses.
Evaluation of the vector competence of a native UK mosquito Ochlerotatus detritus (Aedes detritus) for dengue, chikungunya and West Nile viruses.
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DOI：
10.1186/s13071-016-1739-3
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发表时间：
2016-08-15
影响因子：
3.2
通讯作者：
Baylis M
中科院分区：
文献类型：
--
作者：
Blagrove MS;Sherlock K;Chapman GE;Impoinvil DE;McCall PJ;Medlock JM;Lycett G;Solomon T;Baylis M
迄今为止，尽管英国出现了30多种蚊子，包括虫媒病毒的推定媒介，但没有证据表明蚊子传播的病毒对公共卫生造成了担忧。盐沼蚊虫Ochlerotatus trtraters[syn.伊蚊(Ochlerotatus)碎屑伊蚊在英国部分地区很常见，在那里它可能是人类的贪婪食客。在这里，我们使用从野外获得的未成熟蚊子饲养的成年蚊子来评估碎屑钝蚊对三种主要虫媒病毒：登革病毒(DENV)、基孔肯雅病毒(CHIKV)和西尼罗河病毒(WNV)的能力。我们展示了在21摄氏度下对西尼罗河病毒的实验室能力，在口服接种17天后，在蚊子的唾液中检测到病毒RNA。相比之下，没有证据表明碎屑假单胞菌对DENV或CHIKV具有实验室能力。据我们所知，这是第一项证明英国蚊子对西尼罗河病毒的能力的研究，并证实碎屑蚊可能对英国虫媒病毒的传播构成潜在风险，需要对其在野外的媒介作用进行进一步调查。
To date there has been no evidence of mosquito-borne virus transmission of public health concern in the UK, despite the occurrence of more than 30 species of mosquito, including putative vectors of arboviruses. The saltmarsh mosquito Ochlerotatus detritus [syn. Aedes (Ochlerotatus) detritus] is locally common in parts of the UK where it can be a voracious feeder on people. Here, we assess the competence of O. detritus for three major arboviruses: dengue virus (DENV), chikungunya virus (CHIKV) and West Nile virus (WNV) using adult mosquitoes reared from wild, field-obtained immatures. We demonstrate laboratory competence for WNV at 21 °C, with viral RNA detected in the mosquito’s saliva 17 days after oral inoculation. By contrast, there was no evidence of laboratory competence of O. detritus for either DENV or CHIKV. To our knowledge, this is the first study to demonstrate competence of a UK mosquito for WNV and confirms that O. detritus may present a potential risk for arbovirus transmission in the UK and that further investigation of its vector role in the wild is required.