HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins.
HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins.
复制标题
DOI：
10.1038/cmi.2016.34
复制
发表时间：
2017-01
影响因子：
24.1
通讯作者：
中科院分区：
文献类型：
--
作者：
我们的免疫系统是基于先天和适应性免疫系统的密切合作，以快速检测对宿主的任何威胁。病原体衍生分子的识别被委托给特定的种系编码的信号受体。同样的受体现在也成为错位或改变的自身分子的有效检测器，这些分子在血液供应中断和随后的缺氧后发出组织损伤和细胞死亡的信号。许多类型的内源性分子已被证明在从垂死细胞释放时引起这种无菌炎症状态。然而，一组被称为alarmins的蛋白质具有细胞内和细胞外功能，这一直是深入研究的主题。事实上，alarmins可以发挥有益的细胞管家功能，导致组织修复，或引起有害的不受控制的炎症。这组蛋白包括高迁移率族蛋白1（HMGB 1）、白细胞介素（IL）-1α、IL-33和Ca 2+结合S100蛋白。这些双功能蛋白共享保守的调节机制，如分泌途径、翻译后修饰和酶促加工，其在时间和空间上控制其细胞外功能。间充质细胞释放alarmin是一种高度相关的机制，通过该机制，免疫细胞可以被警告组织损伤，并且alarmin在急性或慢性炎性疾病的发展和癌症发展中起关键作用。
Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline-encoded signaling receptors. The same receptors have now also emerged as efficient detectors of misplaced or altered self-molecules that signal tissue damage and cell death following, for example, disruption of the blood supply and subsequent hypoxia. Many types of endogenous molecules have been shown to provoke such sterile inflammatory states when released from dying cells. However, a group of proteins referred to as alarmins have both intracellular and extracellular functions which have been the subject of intense research. Indeed, alarmins can either exert beneficial cell housekeeping functions, leading to tissue repair, or provoke deleterious uncontrolled inflammation. This group of proteins includes the high-mobility group box 1 protein (HMGB1), interleukin (IL)-1α, IL-33 and the Ca2+-binding S100 proteins. These dual-function proteins share conserved regulatory mechanisms, such as secretory routes, post-translational modifications and enzymatic processing, that govern their extracellular functions in time and space. Release of alarmins from mesenchymal cells is a highly relevant mechanism by which immune cells can be alerted of tissue damage, and alarmins play a key role in the development of acute or chronic inflammatory diseases and in cancer development.
登录
查看更多内容
影响因子：
4.9
作者：
Abdulahad DA;Westra J;Bijzet J;Limburg PC;Kallenberg CG;Bijl M
通讯作者：
Bijl M
影响因子：
16
作者：
Afonina IS;Tynan GA;Logue SE;Cullen SP;Bots M;Lüthi AU;Reeves EP;McElvaney NG;Medema JP;Lavelle EC;Martin SJ
通讯作者：
Martin SJ
影响因子：
5.3
作者：
Bhaskar, Vinay;Yin, Johnny;Kantak, Seema S.
通讯作者：
Kantak, Seema S.
DOI：
10.1073/pnas.1116848108
发表时间：
2011-12-20
影响因子：
11.1
作者：
Berda-Haddad, Yael;Robert, Stephane;Kaplanski, Gilles
通讯作者：
Kaplanski, Gilles
影响因子：
2.6
作者：
Barkauskaite, V.;Ek, M.;Nyberg, F.
通讯作者：
Nyberg, F.