Mitochondrial Fission in Human Diseases.
Mitochondrial Fission in Human Diseases.
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DOI：
10.1007/164_2016_38
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发表时间：
2017
影响因子：
--
通讯作者：
Chipuk JE
中科院分区：
文献类型：
--
作者：
Serasinghe MN;Chipuk JE
线粒体是多细胞生命的重要组成部分-从原始生物到高度复杂的实体，如哺乳动物。线粒体的重要性通过其大量的充分表征的基本功能来强调，例如通过氧化磷酸化（OX-PHOS）产生能量、钙和活性氧物质（ROS）信号传导以及调节细胞凋亡。此外，通过近年来对线粒体的研究，线粒体的新功能和属性正成为人们关注的焦点。特别是，在过去的十年中，线粒体形状和动力学的研究已经取得了特殊的意义，因为它们被发现影响线粒体功能。最近的进展表明，线粒体功能和动力学是相互关联的，并在细胞和生物体水平上保持健康和疾病之间的平衡。例如，过度的线粒体分裂（裂变）与功能缺陷相关，并且涉及从神经退行性疾病到癌症的多种人类疾病。在本章中，我们检查了最近的文献中的线粒体动力学功能的关系，并探讨它如何影响人类疾病的发展和进展。我们还将强调线粒体动力学的治疗操纵在治疗各种人类病理学的影响。
Mitochondria are an essential component of multicellular life – from primitive organisms, to highly complex entities like mammals. The importance of mitochondria is underlined by their plethora of well-characterized essential functions such as energy production through oxidative phosphorylation (OX-PHOS), calcium and reactive oxygen species (ROS) signaling, and regulation of apoptosis. In addition, novel roles and attributes of mitochondria are coming into focus through the recent years of mitochondrial research. In particular, over the past decade the study of mitochondrial shape and dynamics has achieved special significance, as they are found to impact mitochondrial function. Recent advances indicate that mitochondrial function and dynamics are inter-connected, and maintain the balance between health and disease at a cellular and an organismal level. For example, excessive mitochondrial division (fission) is associated with functional defects, and is implicated in multiple human diseases from neurodegenerative diseases to cancer. In this chapter we examine the recent literature on the mitochondrial dynamics–function relationship, and explore how it impacts on the development and progression of human diseases. We will also highlight the implications of therapeutic manipulation of mitochondrial dynamics in treating various human pathologies.