Mongolian Medicine RuXian-I Treatment of Estrogen-Induced Mammary Gland Hyperplasia in Rats Related to TCTP Regulating Apoptosis
Mongolian Medicine RuXian-I Treatment of Estrogen-Induced Mammary Gland Hyperplasia in Rats Related to TCTP Regulating Apoptosis
复制标题
蒙药乳仙一号治疗雌激素所致大鼠乳腺增生与TCTP调节细胞凋亡相关
DOI：
10.1155/2019/1907263
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Wei, Cheng-Xi
中科院分区：
文献类型：
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作者：
Zhang, Jun-Fei;Liu, Jia;Wei, Cheng-Xi
蒙药乳仙Ⅰ号是由30味蒙药组成，是临床治疗乳腺“气速不日勒都森”病（乳腺增生，HMG）的蒙药传统方剂。本论文在前人研究的基础上，进一步探讨了乳腺1号对雌激素诱导的大鼠子宫内膜异位症的治疗机制。乳仙一号对HMG大鼠体重、摄食量无影响，对心、肺、脾、肾五脏无毒性作用。乳仙-1号可降低HMG大鼠乳头直径、乳头高度、器官指数、病理改变，减轻HMG大鼠性激素水平;乳仙-1号可降低乳腺增生组织中TCTP、Mcl-1、Bcl-xL的上调，增加p53、Bax、caspase-9、caspase-3蛋白的下调。乳腺1号对HMG大鼠具有有效的治疗作用，其可能的治疗机制与抗凋亡蛋白TCTP调控细胞凋亡密切相关。
Mongolian medicine RuXian-I is composed of 30 Mongolian herbs, which is a traditional Mongolian recipe for clinical treatment of breast "Qi Su Bu Ri Le Du Sen" disease (hyperplasia of mammary glands, HMG). Based on the previous study, this dissertation further explores the therapeutic mechanism of RuXian-1 on estrogen-induced HMG in rats. RuXian-1 had no effect on the body weight and food intake of HMG rats and had no toxic effects on the five organs (heart, lung, spleen, and kidney). RuXian-1 reduced the diameter and height of nipple, organ index, and pathological changes and alleviated the sex hormone levels oh HMG; RuXian-I reduced the upregulation of TCTP, Mcl-1, and Bcl-xL in breast tissue of mammary gland hyperplasia and increased the downregulation of p53, Bax, caspase-9, and caspase-3 protein. RuXian-1 has an effective therapeutic activity on HMG rats, and its possible therapeutic mechanism is closely related to antiapoptosis protein TCTP-regulated apoptosis.