Nicotine Concentrations in Electronic Cigarette Refill and Do-It-Yourself Fluids
Nicotine Concentrations in Electronic Cigarette Refill and Do-It-Yourself Fluids
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DOI：
10.1093/ntr/ntu080
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发表时间：
2015-02-01
影响因子：
4.7
通讯作者：
Talbot, Prue
中科院分区：
文献类型：
--
作者：
Davis, Barbara;Dang, Michael;Talbot, Prue
简介：方法：采用高效液相色谱法对71种电子烟笔芯液产品和1种DIY产品的尼古丁浓度进行定量检测。将定量数据与制造商标示浓度进行比较。在不同时间购买的重复补充液产品进行了评估，通过视觉比较的流体着色和量化尼古丁concentration.Results：35的54含尼古丁的流体量化尼古丁浓度偏离超过+/- 10%，从制造商的标签，46的50超过标签值。标记为0尼古丁的再填充液中未检测到尼古丁。在未标示尼古丁浓度的5种产品中，3种不含可检测到的尼古丁，而其余2种产品的尼古丁含量超过100 mg/ml，可能用于DIY。18个重复瓶的补充液中有16个的尼古丁浓度差异很大。5家公司中的一家在最近购买的产品中显示出标签准确性的显著改善。在23个重复对，15 23个不同的颜色从他们的mate.Conclusions：尼古丁浓度标签的电子香烟笔芯产品往往是不准确的，但最近在1家公司的产品有所改善。为确保补充液和DIY产品的安全性，有必要建立生产和标签的质量控制指南，并对产品进行纵向监控。
Introduction: We evaluated the accuracy of nicotine concentration labeling on electronic cigarette refill products.Methods: The nicotine concentration of 71 electronic cigarette refill fluid products and 1 related do-it-yourself (DIY) product was quantified using high-performance liquid chromatography. Quantified data were compared with manufacturers labeled concentrations. Duplicate refill fluid products purchased at different times were evaluated by visual comparison of fluid coloration and quantified nicotine concentration.Results: Thirty-five of the 54 nicotine-containing fluids had quantified nicotine concentrations that deviated by more than +/- 10% from the manufacturer labels, with 46 of 50 being in excess of labeled values. Refill fluids labeled as 0 nicotine had no detectable nicotine. Of the 5 products that were unlabeled for nicotine concentration, 3 contained no detectable nicotine, whereas the remaining 2 contained nicotine in excess of 100 mg/ml and may have been intended for DIY use. Sixteen of the 18 duplicate bottles of refill fluid varied greatly in their nicotine concentrations. One of the 5 companies showed significant improvement in labeling accuracy among the most recently purchased products. Of the 23 total duplicate pairs, 15 of 23 varied in coloration from their mates.Conclusions: Nicotine concentration labeling on electronic cigarette refill products was often inaccurate but showed improvement recently in products from 1 company. To ensure the safety of refill fluids and DIY products, it is necessary to establish quality control guidelines for the manufacturing and labeling and to monitor products longitudinally.