Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release.
Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release.
复制标题
比较 MK-801 和苯环己哌啶对儿茶酚胺摄取和 NMDA 诱导的去甲肾上腺素释放的影响。
DOI：
10.1016/0014-2999(88)90235-x
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发表时间：
1988
影响因子：
5
通讯作者：
Johnson,KM
中科院分区：
文献类型：
--
作者：
Snell,LD;Yi,SJ;Johnson,KM
MK-801对N-甲基-D-天冬氨酸诱导的去甲肾上腺素(NE)释放和[~3H]TCP结合的抑制作用强于苯环利定(PCP)。另一方面，MK-801对红藻氨酸刺激的去甲肾上腺素释放的促进作用和对海马区去甲肾上腺素摄取的抑制作用略弱于五氯苯酚。此外，作为纹状体突触体多巴胺摄取的抑制物，MK-801的效力明显低于PCP。这些数据参考MK-801的治疗潜力进行了讨论。
MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.