Down-expression of CD36 in pancreatic adenocarcinoma and its correlation with clinicopathological features and prognosis.
Down-expression of CD36 in pancreatic adenocarcinoma and its correlation with clinicopathological features and prognosis.
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CD36在胰腺癌中的表达下调及其与临床病理特征和预后的相关性
DOI：
10.7150/jca.21046
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发表时间：
2018
影响因子：
3.9
通讯作者：
Cao L
中科院分区：
文献类型：
--
作者：
Jia S;Zhou L;Shen T;Zhou S;Ding G;Cao L
近年来的研究表明，CD 36在肿瘤的发生、发展，尤其是肿瘤的转移中起着关键作用。然而，CD 36在胰腺癌中的表达和作用尚未见报道。本研究旨在探讨CD 36在胰腺癌及相应非肿瘤正常组织中的表达及其与胰腺癌患者临床病理特征和预后的关系。通过对数据库GSE 16515芯片结果的分析，我们发现CD 36在胰腺癌和相应的非肿瘤正常组织中存在显著的差异表达。本研究采用Western blot和免疫组化方法检测胰腺癌细胞和组织中CD 36的表达，结果显示胰腺癌细胞和组织中CD 36的表达明显低于相应的非肿瘤正常组织。通过对临床和病理资料的统计分析，我们发现CD 36低表达预示着TNM分期和CA 19 -9水平较低，但肿瘤体积较大，生存预后较差。提示CD 36可以作为临床病理特征和预后的预测因子，但其矛盾性值得进一步研究。
Recent studies show that CD36 plays a key role in the occurrence and development of tumors, especially in the metastasis of tumors. However, the expression and role of CD36 has not been reported in pancreatic cancer. This study is aimed to explore the expression of CD36 in pancreatic cancer and corresponding non-tumor normal tissues, and its correlation with clinicopathological features and prognosis of pancreatic cancer patients. By analyzing the chip results of database GSE16515, we found that there was significant differential expression of CD36 in pancreatic cancer and corresponding non-tumor normal tissues. In this study, western blot and immunohistochemistry were used to show that the expression of CD36 in pancreatic cancer cells and tissues is significantly lower than that in corresponding non-tumor normal tissues. By statistically analyzing clinical and pathological data, we found that low expression of CD36 predicts lower TNM staging and CA19-9 levels, but larger tumor size and poor survival prognosis. These findings indicated that CD36 can be used as a predictor of clinicopathological features and prognosis, but the contradiction is worthy of our further study.
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影响因子：
6.4
作者：
Olonisakin, Tolani F.;Li, Huihua;Lee, Janet S.
通讯作者：
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DOI：
10.1161/atvbaha.115.307085
发表时间：
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期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
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影响因子：
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作者：
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DOI：
10.1152/ajpendo.00516.2013
发表时间：
2013-12-01
影响因子：
5.1
作者：
Wang, Jie-Mei;Isenberg, Jeffery S.;Chen, Alex F.
通讯作者：
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