Subcortical contribution of corticospinal transmission during visual guided switching movement of arm
Subcortical contribution of corticospinal transmission during visual guided switching movement of arm
复制标题
视觉引导手臂切换运动期间皮质脊髓传输的皮层下贡献
DOI：
10.1093/cercor/bhab214
复制
发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Ohki Y
中科院分区：
文献类型：
--
作者：
Suzuki S ;Nakajima T;Irie S;Ariyasu R;Ohtsuka H;Komiyama T;Ohki Y
在动物实验中，间接皮质脊髓束（CST）系统通过颈中间神经元已被证明介导的运动命令的视觉行为的在线调整，如目标达成。然而，目前尚不清楚类似的CST系统是否能在人类中执行类似的运动行为。为了澄清这一点，我们调查了运动诱发电位（MEP）的变化，手肘肌肉经颅磁刺激，经颅电刺激，或颈髓刺激，而参与者执行的目标达到和切换运动。我们发现，MEP，无论是引起皮层或subcortically，调制取决于方向的开关运动。MEP促进开始在激动剂肌肉的开关活动的发病。此外，尺神经诱导的MEP易化，这可能是由假定的颈部神经元间系统介导的，也增加了MEP易化的发病。在一个病人与皮质偏盲谁表现出转换运动的暗点，MEP促进之前的转换活动。我们的研究结果表明，CST兴奋灵活地调整与切换运动的启动，这可能部分发生在皮层下网络，包括假定的颈部interneuronal系统。
In animal experiments, the indirect corticospinal tract (CST) system via cervical interneurons has been shown to mediate motor commands for online adjustment of visuomotor behaviors, such as target-reaching. However, it is still unclear whether the similar CST system functions to perform similar motor behaviors in humans. To clarify this, we investigated changes in motor-evoked potentials (MEPs) in the elbow muscles following transcranial magnetic stimulation, transcranial electrical stimulation, or cervicomedullary stimulation while participants executed target-reaching and switching movements. We found that the MEP, whether elicited cortically or subcortically, was modulated depending on the direction of the switching movements. MEP facilitation began around the onset of the switching activities in an agonist muscle. Furthermore, ulnar nerve-induced MEP facilitation, which could be mediated by presumed cervical interneuronal systems, also increased at the onset of MEP facilitation. In a patient with cortical hemianopsia who showed switching movements in the scotoma, the MEPs were facilitated just before the switching activities. Our findings suggested that CST excitation was flexibly tuned with the switching movement initiation, which could partly take place in the subcortical networks, including the presumed cervical interneuronal systems.