Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
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DOI：
10.1016/s0092-8674(00)00008-8
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发表时间：
2000-07-07
期刊：
影响因子：
64.5
通讯作者：
Wang, XD
中科院分区：
文献类型：
--
作者：
Du, CY;Fang, M;Wang, XD
我们在这里报告的识别一种新的蛋白质，Smac，它促进细胞色素c/Apaf-1/caspase-9途径中的caspase激活。Smac通过与凋亡抑制蛋白IAP结合并消除其抑制活性来促进caspase-9活化。Smac通常是一种线粒体蛋白，但当细胞发生凋亡时被释放到胞质溶胶中。Smac的凋亡活性需要线粒体的输入和信号肽的切割。Smac的过表达增加了细胞对凋亡刺激的敏感性。Smac是第二种线粒体蛋白，沿着与细胞色素c一起，通过激活半胱天冬酶促进细胞凋亡。
We report here the identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway. Smac promotes caspase-9 activation by binding to inhibitor of apoptosis proteins, IAPs, and removing their inhibitory activity. Smac is normally a mitochondrial protein but is released into the cytosol when cells undergo apoptosis. Mitochondrial import and cleavage of its signal peptide are required for Smac to gain its apoptotic activity. Overexpression of Smac increases cells' sensitivity to apoptotic stimuli. Smac is the second mitochondrial protein, along with cytochrome c, that promotes apoptosis by activating caspases.