Noncoding RNAs in Glioblastoma: Emerging Biological Concepts and Potential Therapeutic Implications.
Noncoding RNAs in Glioblastoma: Emerging Biological Concepts and Potential Therapeutic Implications.
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DOI：
10.3390/cancers13071555
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发表时间：
2021-03-28
期刊：
影响因子：
5.2
通讯作者：
Das S
中科院分区：
文献类型：
--
作者：
Shahzad U;Krumholtz S;Rutka JT;Das S
自人类基因组计划完成以来，非编码RNA（ncRNA）已成为一类重要的遗传调节因子。几类ncRNA，包括microRNA（miRNAs）、长链非编码RNA（lncRNA）、环状RNA（circRNA）和piwi相互作用RNA（piRNA），已被证明在控制发育和疾病过程中发挥重要作用。在这篇文章中，我们讨论了ncRNA在调节胶质母细胞瘤（GBM）的形成和发展中的潜在作用，以及利用ncRNA在GBM中的诊断和治疗潜力的潜在策略。非编码RNA（ncRNA）作为一类新的基因组调控因子，开创了分子生物学的新时代。随着先进的基因测序技术的出现，已经发现了几种不同类型的ncRNA，包括microRNA（miRNAs）、长非编码RNA（lncRNA）、环状RNA（circRNA）和piwi相互作用RNA（piRNA），它们与许多重要的发育和疾病过程相关，并且正在作为临床和治疗靶点被追求。胶质母细胞瘤（GBM）是成人脑中最常见和最致命的癌症，其分子表型研究揭示了几种ncRNA在其发病机制中经常失调。此外，ncRNA调节胶质瘤生物学的许多重要方面，包括肿瘤细胞增殖、迁移、侵袭、凋亡、血管生成和自我更新。在这里，我们提出了不同类别的ncRNA的生物发生的概述，讨论它们的生物学作用，以及它们与胶质瘤的相关性。最后，我们讨论了在临床上治疗靶向ncRNA的潜在方法。
Since the completion of the Human Genome Project, noncoding RNAs (ncRNAs) have emerged as an important class of genetic regulators. Several classes of ncRNAs, which include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and piwi-interacting RNAs (piRNAs), have been shown to play important roles in controlling developmental and disease processes. In this article, we discuss the potential roles of ncRNAs in regulating glioblastoma (GBM) formation and progression as well as potential strategies to exploit the diagnostic and therapeutic potential of ncRNAs in GBM. Noncoding RNAs (ncRNAs) have emerged as a novel class of genomic regulators, ushering in a new era in molecular biology. With the advent of advanced genetic sequencing technology, several different classes of ncRNAs have been uncovered, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and piwi-interacting RNAs (piRNAs), which have been linked to many important developmental and disease processes and are being pursued as clinical and therapeutic targets. Molecular phenotyping studies of glioblastoma (GBM), the most common and lethal cancer of the adult brain, revealed that several ncRNAs are frequently dysregulated in its pathogenesis. Additionally, ncRNAs regulate many important aspects of glioma biology including tumour cell proliferation, migration, invasion, apoptosis, angiogenesis, and self-renewal. Here, we present an overview of the biogenesis of the different classes of ncRNAs, discuss their biological roles, as well as their relevance to gliomagenesis. We conclude by discussing potential approaches to therapeutically target the ncRNAs in clinic.
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