Longitudinal analysis of risk factors for dementia based on Mild Cognitive Impairment Screen results and questionnaire responses from healthy Japanese individuals registered in an online database.
Longitudinal analysis of risk factors for dementia based on Mild Cognitive Impairment Screen results and questionnaire responses from healthy Japanese individuals registered in an online database.
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根据轻度认知障碍筛查结果和在线数据库中注册的健康日本人的问卷调查，对痴呆症危险因素进行纵向分析。
DOI：
10.1016/j.trci.2019.06.003
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Mizusawa H
中科院分区：
文献类型：
--
作者：
Ogawa M;Maruo K;Sone D;Shimada H;Suzuki K;Watanabe H;Matsuda H;Mizusawa H
前言尽管迫切需要开发治疗痴呆症的措施，但还没有开发出疾病修饰药物。为了进行临床试验，需要建立有效的参与者招募方案。为了满足这一需求，为健康个人创建了一个大规模的在线注册系统--橙色计划综合注册系统(IROOP®)。尽管我们以前的研究已经讨论了痴呆的危险因素，但仍有一些因素存在争议，时间间隔很短，只有6个 月。本研究旨在利用IROOP®数据探讨影响认知功能在较长时间间隔18 月内纵向变化的因素。方法本研究评估了在2016年7月5日至2018年1月15日期间在IROOP®注册的473人(男性175人，女性298人；平均年龄59.6 ± 10.1 岁)的纵向变化，他们在基线和常规问卷和轻度认知障碍筛查至少一次后完成了初始问卷和认知功能的简要评估。统计分析使用IBM SPSS，23.0版，用于Windows，用于人口统计学数据，并使用SAS 9.4版的混合程序，用于线性混合效应模型。在每个分析中，统计显著性水平设定为atp<； .05。结果发现，情绪、睡眠、生活质量和包括认知在内的病史影响认知功能的纵向变化。
IntroductionDespite an urgent need for developing remedial measures against dementia, no disease‐modifying drugs have been developed. Efficient protocols for participant recruitment need to be established for conducting clinical trials. To meet this need, a large‐scale online registry system, the Integrated Registry of Orange Plan (IROOP®), was created for healthy individuals. Although the risk factors for dementia have been discussed in our previous studies for a short interval of 6 months, some factors remain controversial. The present study aimed to explore factors affecting longitudinal changes in cognitive function for a longer interval of 18 months using the IROOP®data.MethodsThis study assessed the longitudinal changes in the collated data for predicting the risk of dementia and included 473 individuals (175 men and 298 women; mean age 59.6 ± 10.1 years) registered in the IROOP®between July 5, 2016 and January 15, 2018 who completed the initial questionnaire and brief assessment of cognitive function (Mild Cognitive Impairment Screen) at baseline and the regular questionnaire and the Mild Cognitive Impairment Screen at least once after baseline. Statistical analyses were performed using IBM SPSS, version 23.0, for Windows for demographic data and the MIXED procedure in SAS, version 9.4, for the linear mixed‐effect model. In each analysis, the statistical significance level was set atP< .05.ResultsMood, sleep, quality of life, and medical histories including cognition were found to influence longitudinal changes in cognitive function.DiscussionGiven the multifactorial etiology of dementia, preventive measures targeting multiple domains are required for maintaining cognitive function, instead of focusing on one lifestyle factor.