Plasma levels of receptor interacting protein kinase-3 correlated with coronary artery disease
Plasma levels of receptor interacting protein kinase-3 correlated with coronary artery disease
复制标题
受体相互作用蛋白激酶 3 的血浆水平与冠状动脉疾病相关
DOI：
10.1097/cm9.0000000000000225
复制
发表时间：
2019-06-20
影响因子：
6.1
通讯作者：
Zhang, Shu-Yang
中科院分区：
文献类型：
--
作者：
Hu, Xiao-Min;Chen, Xi;Zhang, Shu-Yang
背景：坏死性凋亡在人类动脉粥样硬化和动脉粥样硬化的发展中起重要作用。由于受体相互作用蛋白激酶3（RIP3）是坏死性凋亡的关键介质，本研究旨在探讨血浆RIP3水平与冠状动脉疾病（CAD）的关系，并发现一种潜在的新的筛选CAD亚型和严重程度的生物标志物。2017年9月至2018年1月在北京协和医院接受冠状动脉造影的CAD患者共318例，对照组166例参加了这项研究。冠心病患者分为三个亚组：稳定性冠状动脉疾病（SCAD）患者、不稳定性心绞痛（UA）患者和心肌梗死（MI）患者。采用Gensini评分（GSS）评价动脉粥样硬化的严重程度。采用Logistic回归分析血浆RIP3水平与冠心病的关系。结果：总体而言，血浆RIP3水平显著高于血清RIP3水平。冠心病患者血浆RIP3水平显著高于对照组。血浆RIP3水平与CAD密切相关（比值比：6.00，95%置信区间3.04 - 11.81; P <0.001）。从对照组到SCAD患者，然后是UA患者，最后是MI患者，血浆RIP3水平呈线性增加。我们发现受试者中急性冠状动脉综合征的病例比例与其血浆RIP3水平四分位数之间存在显著正相关。血浆RIP3水平也与GSS相关（B 0.027;标准误0.012; P <0.05）。血浆RIP 3水平可能会补充临床评估，以筛查CAD并确定CAD严重程度。
Background: Necroptosis plays an important role in human atherosclerosis and atheroma development. Since receptor interacting protein kinase-3 (RIP3) acts as a key mediator of necroptosis, this study aimed to explore its relationship between plasma RIP3 levels and coronary artery disease (CAD) and discover a potential new biomarker for screening CAD subtypes and severity.Methods: A total of 318 patients with CAD who had coronary angiography and 166 controls in Peking Union Medical College Hospital from September 2017 to January 2018 were enrolled in this study. Patients with CAD were divided into three subgroups: patients with stable coronary artery disease (SCAD), patients with unstable angina (UA), and patients with myocardial infarction (MI). The severity of atherosclerosis was determined by Gensini score (GSS). Logistic regression was used to determine the relationship between plasma RIP3 levels and CAD. The correlation between plasma RIP3 and GSS was calculated using multiple linear regression models.Results: Overall, plasma RIP3 levels were significantly higher than serum RIP3 levels. Plasma RIP3 levels in patients with CAD were significantly higher than those in controls. Plasma RIP3 levels were strongly associated with CAD (odds ratio: 6.00, 95% confidence interval 3.04-11.81; P < 0.001). Plasma RIP3 levels increased linearly from controls to patients with SCAD, then patients with UA, and finally to patients with MI. We found a significantly positive correlation between proportion of cases of acute coronary syndrome in subjects and their plasma RIP3 level quartile. Plasma RIP3 levels were also associated with GSS (B 0.027; standard error 0.012; P < 0.05).Conclusions: Plasma RIP3 levels were independently associated with CAD. Plasma RIP3 levels could potentially supplement clinical assessment to screen CAD and determine CAD severity.