AASLD guidelines for the treatment of hepatocellular carcinoma
AASLD guidelines for the treatment of hepatocellular carcinoma
复制标题
AASLD 肝细胞癌治疗指南
DOI：
10.1002/hep.29086
复制
发表时间：
2018-01-01
期刊：
影响因子：
13.5
通讯作者：
Marrero, Jorge A.
中科院分区：
文献类型：
--
作者：
Heimbach, Julie K.;Kulik, Laura M.;Marrero, Jorge A.
本文件介绍了美国肝脏疾病研究协会（AASLD）关于成人肝硬化背景下发生的肝细胞癌（HCC）的监测、诊断和治疗的官方建议。与以前的AASLD实践指南不同，目前的指南是根据医学研究所关于可信赖实践指南的标准制定的，并使用了推荐评估、发展和评估分级（GRADE）方法。(1)对文献进行了多项系统综述，以支持本实践指南中的建议。通过阅读系统评价的适用部分，可以加深对指南的理解。此外，更多详细信息可在相关指南文件中找到，该指南涉及HCC临床重要方面，缺乏足够的证据来保证系统性综述，该指南侧重于广泛的临床实践，包括肝硬化患者的HCC监测，确定HCC的诊断，以及HCC治疗的各种治疗选择。为了解决HCC的其他问题，如流行病学，分期和诊断和治疗的其他方面，作者创建了一个新的指导文件，该文件将很快出版，并基于Bruix和谢尔曼以前的HCC AASLD指南。（二）
This document presents official recommendations of the American Association for the Study of Liver Diseases (AASLD) on the surveillance, diagnosis, and treatment of hepatocellular carcinoma (HCC) occurring in the setting of adults with cirrhosis. Unlike previous AASLD practice guidelines, the current guideline was developed in compliance with the Institute of Medicine standards for trustworthy practice guidelines and uses the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach.(1) Multiple systematic reviews of the literature were conducted to support the recommendations in this practice guideline. An enhanced understanding of the guideline can be obtained by reading the applicable portions of the systematic reviews. In addition, more detailed information may be found in the associated guidance document related to clinically important aspects of HCC that lacked sufficient evidence to warrant a systematic review.The guideline focuses on a broad spectrum of clinical practice, including surveillance of patients with cirrhosis for HCC, establishing the diagnosis of HCC, and various therapeutic options for the treatment of HCC. To address other issues on HCC such as epidemiology, staging, and additional aspects of diagnosis and treatment, the authors have created a new guidance document that will be published soon and is based upon the previous HCC AASLD guidelines by Bruix and Sherman.(2)