ANALYSIS OF TIME-DEPENDENT RISKS FOR INFECTION, REJECTION, AND DEATH AFTER PULMONARY TRANSPLANTATION
ANALYSIS OF TIME-DEPENDENT RISKS FOR INFECTION, REJECTION, AND DEATH AFTER PULMONARY TRANSPLANTATION
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DOI：
10.1016/s0022-5223(95)70419-1
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发表时间：
1995-01-01
影响因子：
6
通讯作者：
GRIFFITH, BP
中科院分区：
文献类型：
--
作者：
BANDO, K;PARADIS, IL;GRIFFITH, BP
感染和排斥反应仍然是肺移植受者生存的最大威胁。此外，这些事件之间可能存在关系，因为一个事件的发生可能会导致另一个事件的发生。通过对重复事件进行多变量分析，我们分析了1988年1月至1993年9月间接受250例同种异体肺移植的239例肺移植受者中细菌、真菌和病毒感染、II级或更高级别急性排斥反应和死亡的危险因素。在6至71个月的随访期间，共发生90例死亡，491例急性排斥反应和542例感染事件。死亡、感染和排斥反应的危险或风险模式在移植后的前100天内均为极高风险，在800至1200天内为第二个中等风险期，以及较低的恒定风险。感染和移植失败表现为弥漫性肺泡损伤是早期死亡的主要原因（
Infection and rejection remain the greatest threats to the survival of pulmonary allograft recipients. Furthermore, a relationship may exist between these events, because the occurrence of one may predispose to the other. By using multivariate analysis for repeated events, we analyzed the risk factors for bacterial, fungal, and viral infection, grade II or greater acute rejection, and death among 239 lung transplant recipients who received 250 allografts between January 1988 and September 1993. A total of 90 deaths, 491 episodes of acute rejection, and 542 infectious episodes occurred during a follow-up of 6 to 71 months. The hazard or risk patterns of death, infection, and rejection each followed an extremely high risk during the first 100 days after transplantation, a second modest risk period at 800 to 1200 days, and a lower constant risk. Infection and graft failure manifested by diffuse alveolar damage were the major causes of early death (